PMID- 36613093
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230220
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Dec 31
TI  - Minimal Clinically Important Differences (MCID) for the Functional Assessment of 
      Chronic Illness Therapy Fatigue Scale in Patients with Systemic Sclerosis.
LID - 10.3390/ijerph20010771 [doi]
LID - 771
AB  - (1) Background: Systemic sclerosis (SSc) is characterized by significant fatigue, 
      causing diminished quality of life (QoL). The aim of this study was to examine 
      fatigue levels and their associations with clinical factors and determine the 
      minimal clinically important difference (MCID) value for the Functional 
      Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-FS). (2) Methods: A 
      total of 160 SSc patients and 62 individuals without SSc were followed-up over a 
      12-month period by measuring the FACIT-FS and the Visual Analogue Scale and the 
      Short Form 36 Vitality Score analyzing changes in exhaustion. (3) Results: 
      Fatigue was strongly correlated with HRQoL, level of pain, emotional disorders, 
      physical capability and functionality. The MCID values for FACIT-FS were 
      calculated as -3 for deterioration and +4 for improvement after a 12-month 
      follow-up. The predictors of improvement of fatigue from baseline parameters were 
      the significant disease activity, the patients' poorer functionality and the 
      short disease duration. Patients with scleroderma-related interstitial lung 
      disease at baseline had approximately tripled risks for worsening fatigue. The 
      independent influential factors regarding the changing of FACIT-FS were improving 
      or worsening in the same direction in reference to physical condition, 
      gastrointestinal and emotional factors. (4) Conclusions: Fatigue is a 
      multi-dimensional symptom, which is strongly correlated to HRQoL. MCID values of 
      FACIT-FS can be useful tools in monitoring the changes of HRQoL in clinical 
      trials and in daily practice among patients with SSc.
FAU - Kiss, Franciska
AU  - Kiss F
AUID- ORCID: 0000-0003-0705-635X
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
FAU - Farkas, Nelli
AU  - Farkas N
AD  - Institute of Bioanalysis, Medical School, University of Pecs, H-7624 Pecs, 
      Hungary.
FAU - Nagy, Gabriella
AU  - Nagy G
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
FAU - Minier, Tunde
AU  - Minier T
AUID- ORCID: 0000-0003-0983-2092
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
FAU - Kumanovics, Gabor
AU  - Kumanovics G
AUID- ORCID: 0000-0001-8500-2918
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
FAU - Faludi, Reka
AU  - Faludi R
AUID- ORCID: 0000-0002-8812-7000
AD  - Heart Institute, Medical School, University of Pecs, H-7624 Pecs, Hungary.
FAU - Czirjak, Laszlo
AU  - Czirjak L
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
FAU - Varju, Cecilia
AU  - Varju C
AUID- ORCID: 0000-0002-6849-9114
AD  - Department of Rheumatology and Immunology, Medical School, University of Pecs, 
      H-7632 Pecs, Hungary.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221231
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Humans
MH  - Quality of Life
MH  - Minimal Clinically Important Difference
MH  - *Scleroderma, Systemic/complications
MH  - *Lung Diseases
MH  - Fatigue
MH  - Severity of Illness Index
MH  - Chronic Disease
PMC - PMC9819291
OTO - NOTNLM
OT  - fatigue
OT  - fatigue scale
OT  - functional assessment of chronic illness therapy
OT  - health-related quality of life
OT  - minimal clinically important difference
OT  - systemic sclerosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/11 06:00
PMCR- 2022/12/31
CRDT- 2023/01/08 01:16
PHST- 2022/11/30 00:00 [received]
PHST- 2022/12/28 00:00 [revised]
PHST- 2022/12/29 00:00 [accepted]
PHST- 2023/01/08 01:16 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/31 00:00 [pmc-release]
AID - ijerph20010771 [pii]
AID - ijerph-20-00771 [pii]
AID - 10.3390/ijerph20010771 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Dec 31;20(1):771. doi: 
      10.3390/ijerph20010771.