PMID- 36613538
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230111
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 1
DP  - 2022 Dec 21
TI  - Bacterial DNAemia in Alzheimer's Disease and Mild Cognitive Impairment: 
      Association with Cognitive Decline, Plasma BDNF Levels, and Inflammatory 
      Response.
LID - 10.3390/ijms24010078 [doi]
LID - 78
AB  - Microbial dysbiosis (MD) provokes gut barrier alterations and bacterial 
      translocation in the bloodstream. The increased blood bacterial DNA (BB-DNA) may 
      promote peripheral- and neuro-inflammation, contributing to cognitive impairment. 
      MD also influences brain-derived neurotrophic factor (BDNF) production, whose 
      alterations contribute to the etiopathogenesis of Alzheimer's disease (AD). The 
      purpose of this study is to measure BB-DNA in healthy elderly controls (EC), and 
      in patients with mild cognitive impairment (MCI) and AD to explore the effect on 
      plasma BDNF levels (pBDNF), the inflammatory response, and the association with 
      cognitive decline during a two-year follow-up. Baseline BB-DNA and pBDNF were 
      significantly higher in MCI and AD than in EC. BB-DNA was positively correlated 
      with pBDNF in AD, plasma Tumor necrosis factor-alpha (TNF-alpha), and Interleukin-10 
      (IL-10) levels in MCI. AD patients with BB-DNA values above the 50th percentile 
      had lower baseline Mini-Mental State Examination (MMSE). After a two-year 
      follow-up, AD patients with the highest BB-DNA tertile had a worse cognitive 
      decline, while higher BB-DNA levels were associated with higher TNF-alpha and lower 
      IL-10 in MCI. Our study demonstrates that, in early AD, the higher the BB-DNA 
      levels, the higher the pBDNF levels, suggesting a defensive attempt; BB-DNA seems 
      to play a role in the AD severity/progression; in MCI, higher BB-DNA may trigger 
      an increased inflammatory response.
FAU - Giacconi, Robertina
AU  - Giacconi R
AUID- ORCID: 0000-0002-1468-2140
AD  - Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
FAU - D'Aquila, Patrizia
AU  - D'Aquila P
AUID- ORCID: 0000-0001-5740-4733
AD  - Department of Biology, Ecology and Earth Sciences (DIBEST), University of 
      Calabria, 87036 Rende, Italy.
FAU - Balietti, Marta
AU  - Balietti M
AD  - Center for Neurobiology of Aging, IRCCS INRCA, 60121 Ancona, Italy.
FAU - Giuli, Cinzia
AU  - Giuli C
AUID- ORCID: 0000-0001-8826-2467
AD  - Geriatrics Operative Unit, IRCCS INRCA, 63900 Fermo, Italy.
FAU - Malavolta, Marco
AU  - Malavolta M
AUID- ORCID: 0000-0002-8442-1763
AD  - Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
FAU - Piacenza, Francesco
AU  - Piacenza F
AUID- ORCID: 0000-0001-7440-804X
AD  - Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
FAU - Costarelli, Laura
AU  - Costarelli L
AUID- ORCID: 0000-0001-8107-9061
AD  - Clinical Laboratory & Molecular Diagnostics, IRCCS INRCA, 60121 Ancona, Italy.
FAU - Postacchini, Demetrio
AU  - Postacchini D
AD  - Geriatrics Operative Unit, IRCCS INRCA, 63900 Fermo, Italy.
FAU - Passarino, Giuseppe
AU  - Passarino G
AUID- ORCID: 0000-0003-4701-9748
AD  - Department of Biology, Ecology and Earth Sciences (DIBEST), University of 
      Calabria, 87036 Rende, Italy.
FAU - Bellizzi, Dina
AU  - Bellizzi D
AUID- ORCID: 0000-0001-9986-456X
AD  - Department of Biology, Ecology and Earth Sciences (DIBEST), University of 
      Calabria, 87036 Rende, Italy.
FAU - Provinciali, Mauro
AU  - Provinciali M
AUID- ORCID: 0000-0002-0568-3002
AD  - Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
LA  - eng
GR  - 154/GR-2009-1584108/Governo Italiano/
GR  - PON ARS01_00568 to G.P./Governo Italiano/
PT  - Journal Article
DEP - 20221221
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Biomarkers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Humans
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor
MH  - Interleukin-10
MH  - *Alzheimer Disease/diagnosis
MH  - Tumor Necrosis Factor-alpha
MH  - Biomarkers
MH  - *Cognitive Dysfunction
MH  - DNA
PMC - PMC9820596
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - circulating bacterial DNA
OT  - inflammation
OT  - mild cognitive impairment
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/11 06:00
PMCR- 2022/12/21
CRDT- 2023/01/08 01:19
PHST- 2022/11/01 00:00 [received]
PHST- 2022/12/13 00:00 [revised]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/01/08 01:19 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/21 00:00 [pmc-release]
AID - ijms24010078 [pii]
AID - ijms-24-00078 [pii]
AID - 10.3390/ijms24010078 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Dec 21;24(1):78. doi: 10.3390/ijms24010078.