PMID- 36613559
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230308
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 1
DP  - 2022 Dec 21
TI  - Fatty-Acid-Based Membrane Lipidome Profile of Peanut Allergy Patients: An 
      Exploratory Study of a Lifelong Health Condition.
LID - 10.3390/ijms24010120 [doi]
LID - 120
AB  - Peanut allergy is a lifelong, increasingly prevalent, and potentially 
      life-threatening disease burdening families and communities. Dietary, 
      particularly polyunsaturated fatty acids (PUFAs), intakes can exert positive 
      effects on immune and inflammatory responses, and the red blood cell (RBC) 
      membrane lipidome contains stabilized metabolic and nutritional information 
      connected with such responses. The fatty-acid-based membrane lipidome profile has 
      been exploratorily evaluated in a small cohort of patients (eight males and one 
      female, age range 4.1-21.7 years old, body mass index BMI < 25) with angioedema 
      and/or anaphylaxis after peanut ingestion. This analysis was performed according 
      to an ISO 17025 certified robotic protocol, isolating mature RBCs, extracting 
      membrane lipids, and transforming them to fatty acid methyl esters for gas 
      chromatography recognition and quantification. Comparison with a group of age- 
      and BMI-matched healthy individuals and with benchmark interval values of a 
      healthy population evidenced significant differences, such as higher levels of 
      omega-6 (arachidonic acid), lower values of omega-3 eicosapentaenoic acid (EPA) and 
      docosahexaenoic acid (DHA), together with an increased omega-6/omega-3 ratio in allergic 
      patients. A significant inverse correlation was also found between specific 
      immunoglobulin E (IgE) levels and omega-6 di-homo-gamma-linolenic acid (DGLA) and 
      total PUFAs. Results of this preliminary study encourage screenings in larger 
      cohorts, also in view of precision nutrition and nutraceuticals strategies, and 
      stimulate interest to expand basic and applied research for unveiling molecular 
      mechanisms that are still missing and individuating treatments in chronic 
      allergic disorders.
FAU - Del Duca, Elisabetta
AU  - Del Duca E
AD  - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, 
      University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
FAU - Sansone, Anna
AU  - Sansone A
AUID- ORCID: 0000-0003-0865-4861
AD  - ISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, 
      Italy.
FAU - Sgrulletti, Mayla
AU  - Sgrulletti M
AUID- ORCID: 0000-0002-7493-5226
AD  - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, 
      University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
AD  - PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, 
      University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
FAU - Di Nolfo, Federica
AU  - Di Nolfo F
AD  - Lipidomic Laboratory, Lipinutragen Srl, Via di Corticella 181/4, 40128 Bologna, 
      Italy.
FAU - Chini, Loredana
AU  - Chini L
AD  - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, 
      University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
FAU - Ferreri, Carla
AU  - Ferreri C
AUID- ORCID: 0000-0002-1359-0869
AD  - ISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, 
      Italy.
FAU - Moschese, Viviana
AU  - Moschese V
AD  - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, 
      University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221221
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Child, Preschool
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Fatty Acids
MH  - *Peanut Hypersensitivity
MH  - Lipidomics
MH  - *Fatty Acids, Omega-3
MH  - Eicosapentaenoic Acid/metabolism
MH  - Docosahexaenoic Acids/metabolism
PMC - PMC9820545
OTO - NOTNLM
OT  - allergic inflammation
OT  - membrane lipidome
OT  - peanut allergy
OT  - polyunsaturated fatty acids
OT  - red blood cell
OT  - omega-3 fatty acids
OT  - omega-6 fatty acids
COIS- C.F. is a cofounder of Lipinutragen srl, a spin-off of the CNR dedicated to 
      membrane lipidomic analysis in human health. F.D.N. is an employee of 
      Lipinutragen srl. This company did not have any role in the design and conduction 
      of the present study.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/11 06:00
PMCR- 2022/12/21
CRDT- 2023/01/08 01:19
PHST- 2022/11/03 00:00 [received]
PHST- 2022/12/14 00:00 [revised]
PHST- 2022/12/15 00:00 [accepted]
PHST- 2023/01/08 01:19 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/21 00:00 [pmc-release]
AID - ijms24010120 [pii]
AID - ijms-24-00120 [pii]
AID - 10.3390/ijms24010120 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Dec 21;24(1):120. doi: 10.3390/ijms24010120.