PMID- 36613859
OWN - NLM
STAT- MEDLINE
DCOM- 20230111
LR  - 20231106
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 1
DP  - 2022 Dec 27
TI  - Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the 
      Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 
      Infection.
LID - 10.3390/ijms24010415 [doi]
LID - 415
AB  - In patients with severe pneumonia due to COVID-19, the deregulation of oxidative 
      stress is present. Nuclear erythroid factor 2 (NRF2) is regulated by KEAP1, and 
      NRF2 regulates the expression of genes such as NFE2L2-KEAP1, which are involved 
      in cellular defense against oxidative stress. In this study, we analyzed the 
      participation of the polymorphisms of NFE2L2 and KEAP1 genes in the mechanisms of 
      damage in lung disease patients with SARS-CoV-2 infection. Patients with COVID-19 
      and a control group were included. Organ dysfunction was evaluated using SOFA. 
      SARS-CoV-2 infection was confirmed and classified as moderate or severe by 
      ventilatory status and by the Berlin criteria for acute respiratory distress 
      syndrome. SNPs in the gene locus for NFE2L2, rs2364723C>G, and KEAP1, 
      rs9676881A>G, and rs34197572C>T were determined by qPCR. We analyzed 110 
      individuals with SARS-CoV-2 infection: 51 with severe evolution and 59 with 
      moderate evolution. We also analyzed 111 controls. Significant differences were 
      found for rs2364723 allele G in severe cases vs. controls (p = 0.02); for the 
      rs9676881 allele G in moderate cases vs. controls (p = 0.04); for the rs34197572 
      allele T in severe cases vs. controls (p = 0.001); and in severe vs. moderate 
      cases (p = 0.004). Our results showed that NFE2L2 rs2364723C>G allele G had a 
      protective effect against severe COVID-19, while KEAP1 rs9676881A>G allele G and 
      rs34197572C>T minor allele T were associated with more aggressive stages of 
      COVID-19.
FAU - Soto, Maria Elena
AU  - Soto ME
AUID- ORCID: 0000-0003-1332-2888
AD  - Department of Immunology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
AD  - Cardiovascular Line in American British Cowdray (ABC) Medical Center, I.A.P. ABC 
      I.A.P. ABC Sur 136 No. 116 Col. Las Americas, Mexico City 01120, Mexico.
FAU - Fuentevilla-Alvarez, Giovanny
AU  - Fuentevilla-Alvarez G
AUID- ORCID: 0000-0002-1819-8444
AD  - Department of Physiology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
AD  - Department of Biochemistry, Escuela Nacional de Ciencias Biologicas, Instituto 
      Politecnico Nacional (IPN), Manuel Carpio y Plutarco Elias Calles, Col. Miguel 
      Hidalgo, Mexico City 11350, Mexico.
FAU - Palacios-Chavarria, Adrian
AU  - Palacios-Chavarria A
AUID- ORCID: 0000-0003-2299-1581
AD  - Critical Care Unit of the Temporal COVID-19 Unit, Citibanamex Center Av. del 
      Conscripto 311, Lomas de Sotelo, Hipodromo de las Americas, Miguel Hidalgo, 
      Mexico City 11200, Mexico.
FAU - Vazquez, Rafael Ricardo Valdez
AU  - Vazquez RRV
AD  - Critical Care Unit of the Temporal COVID-19 Unit, Citibanamex Center Av. del 
      Conscripto 311, Lomas de Sotelo, Hipodromo de las Americas, Miguel Hidalgo, 
      Mexico City 11200, Mexico.
FAU - Herrera-Bello, Hector
AU  - Herrera-Bello H
AD  - Critical Care Unit of the Temporal COVID-19 Unit, Citibanamex Center Av. del 
      Conscripto 311, Lomas de Sotelo, Hipodromo de las Americas, Miguel Hidalgo, 
      Mexico City 11200, Mexico.
FAU - Moreno-Castaneda, Lidia
AU  - Moreno-Castaneda L
AD  - Critical Care Unit of the Temporal COVID-19 Unit, Citibanamex Center Av. del 
      Conscripto 311, Lomas de Sotelo, Hipodromo de las Americas, Miguel Hidalgo, 
      Mexico City 11200, Mexico.
FAU - Torres-Paz, Yazmin Estela
AU  - Torres-Paz YE
AD  - Department of Physiology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
FAU - Gonzalez-Moyotl, Nadia Janet
AU  - Gonzalez-Moyotl NJ
AUID- ORCID: 0000-0003-0672-5048
AD  - Department of Physiology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
FAU - Perez-Torres, Idalia
AU  - Perez-Torres I
AD  - Department of Genetic, Hospital Infantil de Mexico "Federico Gomez", Doctor 
      Marquez 162, Col. Doctores, Mexico City 06720, Mexico.
FAU - Aisa-Alvarez, Alfredo
AU  - Aisa-Alvarez A
AD  - Critical Care Unit of the Temporal COVID-19 Unit, Citibanamex Center Av. del 
      Conscripto 311, Lomas de Sotelo, Hipodromo de las Americas, Miguel Hidalgo, 
      Mexico City 11200, Mexico.
AD  - Critical Care in American British Cowdray (ABC) Medical Center, I.A.P. ABC I.A.P. 
      ABC Sur 136 No. 116 Col. Las Americas, Mexico City 01120, Mexico.
FAU - Manzano-Pech, Linaloe
AU  - Manzano-Pech L
AD  - Department of Cardiovascular Biomedicine, Instituto Nacional de Cardiologia 
      "Ignacio Chavez", Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, 
      Mexico.
FAU - Perez-Torres, Israel
AU  - Perez-Torres I
AUID- ORCID: 0000-0001-6510-2954
AD  - Department of Cardiovascular Biomedicine, Instituto Nacional de Cardiologia 
      "Ignacio Chavez", Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, 
      Mexico.
FAU - Huesca-Gomez, Claudia
AU  - Huesca-Gomez C
AD  - Department of Physiology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
FAU - Gamboa, Ricardo
AU  - Gamboa R
AUID- ORCID: 0000-0001-9102-4240
AD  - Department of Physiology, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      Juan Badiano No. 1. Col. Seccion XVI., Mexico City 14380, Mexico.
LA  - eng
GR  - 312167/Consejo Nacional de Ciencia y Tecnologia/
PT  - Journal Article
DEP - 20221227
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (KEAP1 protein, human)
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Humans
MH  - *COVID-19/genetics
MH  - Genetic Predisposition to Disease
MH  - *Kelch-Like ECH-Associated Protein 1/genetics/metabolism
MH  - *NF-E2-Related Factor 2/genetics/metabolism
MH  - SARS-CoV-2
PMC - PMC9820269
OTO - NOTNLM
OT  - COVID-19
OT  - KEAP1
OT  - NFE2L2
OT  - SARS-CoV-2
OT  - inflammation
OT  - pathogenesis
OT  - single nucleotide polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/11 06:00
PMCR- 2022/12/27
CRDT- 2023/01/08 01:22
PHST- 2022/10/21 00:00 [received]
PHST- 2022/12/08 00:00 [revised]
PHST- 2022/12/13 00:00 [accepted]
PHST- 2023/01/08 01:22 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/27 00:00 [pmc-release]
AID - ijms24010415 [pii]
AID - ijms-24-00415 [pii]
AID - 10.3390/ijms24010415 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Dec 27;24(1):415. doi: 10.3390/ijms24010415.