PMID- 36615124
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Dec 31
TI  - Impact of Type 2 Diabetes Mellitus on the Prognosis of Non-Small Cell Lung 
      Cancer.
LID - 10.3390/jcm12010321 [doi]
LID - 321
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is the most common metabolic disease 
      and is characterized by sustained hyperglycemia. The impact of T2DM on the 
      survival of lung cancer patients remains controversial. The aim of this study was 
      to investigate the associations of type 2 diabetes with lung cancer mortality. 
      METHODS: From January 2019 to January 2020, 228 patients with non-small cell lung 
      cancer (NSCLC) staging earlier than IIIA were included. RESULTS: In our study, we 
      found that the overall survival (OS) and progression-free survival (PFS) of lung 
      cancer patients with diabetes was longer than non-diabetes group. Diagnosed T2DM 
      was associated with the prognosis of lung cancer after adjusting for age and 
      covariates. The association between T2DM and OS was influenced by age, stage of 
      cancer and cancer treatment, as well as whether taking metformin was associated 
      with the OS of lung cancer. However, with the adjustment for age and covariates, 
      the relation trended to lose statistical significance. CONCLUSION: T2DM is an 
      independent prognostic factor for patients with NSCLC staging before IIIA. The 
      patients with both NSCLC and T2DM trended to having a longer OS, possibly due to 
      metformin.
FAU - Lu, You
AU  - Lu Y
AUID- ORCID: 0000-0001-9396-5562
AD  - Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji 
      University School of Medicine, Shanghai 200072, China.
FAU - Hu, Yaohua
AU  - Hu Y
AD  - Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong 
      University, Shanghai 200025, China.
FAU - Zhao, Yi
AU  - Zhao Y
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
FAU - Xie, Shuanshuan
AU  - Xie S
AD  - Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji 
      University School of Medicine, Shanghai 200072, China.
FAU - Wang, Changhui
AU  - Wang C
AD  - Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji 
      University School of Medicine, Shanghai 200072, China.
LA  - eng
PT  - Journal Article
DEP - 20221231
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9821111
OTO - NOTNLM
OT  - diabetes
OT  - metformin
OT  - non-small cell lung cancer
OT  - prognosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/09 06:01
PMCR- 2022/12/31
CRDT- 2023/01/08 01:32
PHST- 2022/11/23 00:00 [received]
PHST- 2022/12/24 00:00 [revised]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/01/08 01:32 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/09 06:01 [medline]
PHST- 2022/12/31 00:00 [pmc-release]
AID - jcm12010321 [pii]
AID - jcm-12-00321 [pii]
AID - 10.3390/jcm12010321 [doi]
PST - epublish
SO  - J Clin Med. 2022 Dec 31;12(1):321. doi: 10.3390/jcm12010321.