PMID- 36615150
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 1
DP  - 2023 Jan 2
TI  - Predictive Factors of Cytomegalovirus Viremia during the Clinical Course of 
      Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Single 
      Center Observational Study.
LID - 10.3390/jcm12010351 [doi]
LID - 351
AB  - We aim to elucidate factors to aid in the prediction of cytomegalovirus viremia 
      during the treatment of anti-neutrophil cytoplasmic antibody-associated 
      vasculitis (AAV). We conducted a single-center, retrospective, observational 
      study of 35 patients with newly diagnosed AAV. Factors associated with the 
      development of CMV viremia were investigated via a logistic regression analysis. 
      The CMV antigenemia test was performed in 25 patients (71%), of whom 15 (60%) 
      were diagnosed with CMV viremia. Of these 15 patients, 5 developed a CMV 
      infection. The total protein, hemoglobin, platelet count and lymphocyte counts at 
      the time of the CMV antigenemia test were significantly lower in patients who 
      developed CMV viremia. In addition, total protein, hemoglobin, platelet count and 
      lymphocyte count also presented significantly decreasing trends in the following 
      order: patients who did not develop CMV viremia, patients who developed CMV 
      viremia without any symptoms, and patients who developed CMV infection. All 
      patients with CMV recovered. In conclusion, the total protein, hemoglobin, 
      platelet count and lymphocyte count may be useful markers for the prediction of 
      CMV viremia and infection after the start of induction of immunosuppressive 
      therapy for patients with AAV.
FAU - Harada, Makoto
AU  - Harada M
AUID- ORCID: 0000-0002-6209-7683
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Iwabuchi, Ryohei
AU  - Iwabuchi R
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Yamaguchi, Akinori
AU  - Yamaguchi A
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Aomura, Daiki
AU  - Aomura D
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Yamada, Yosuke
AU  - Yamada Y
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Sonoda, Kosuke
AU  - Sonoda K
AUID- ORCID: 0000-0001-9886-6467
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Kamimura, Yutaka
AU  - Kamimura Y
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Hashimoto, Koji
AU  - Hashimoto K
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Kamijo, Yuji
AU  - Kamijo Y
AUID- ORCID: 0000-0001-8077-891X
AD  - Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto 390-8621, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230102
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9821060
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody (ANCA)
OT  - anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
OT  - cytomegalovirus
OT  - cytomegalovirus infection
OT  - cytomegalovirus viremia
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/09 06:01
PMCR- 2023/01/02
CRDT- 2023/01/08 01:32
PHST- 2022/11/16 00:00 [received]
PHST- 2022/12/08 00:00 [revised]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/01/08 01:32 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/09 06:01 [medline]
PHST- 2023/01/02 00:00 [pmc-release]
AID - jcm12010351 [pii]
AID - jcm-12-00351 [pii]
AID - 10.3390/jcm12010351 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jan 2;12(1):351. doi: 10.3390/jcm12010351.