PMID- 36615851 OWN - NLM STAT- MEDLINE DCOM- 20230216 LR - 20230216 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 15 IP - 1 DP - 2022 Dec 30 TI - Relationship between the Dietary Inflammatory Index Score and Cytokine Levels in Chinese Pregnant Women during the Second and Third Trimesters. LID - 10.3390/nu15010194 [doi] LID - 194 AB - The impact of dietary inflammatory potential on serum cytokine concentrations in second and third trimesters of Chinese pregnant women is not clear. A total of 175 pregnant women from the Tianjin Maternal and Child Health Education and Service Cohort (TMCHESC) were included. The dietary inflammatory index (DII) was calculated based on 24-h food records. Serum tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-8, IL-10, C-reactive protein (CRP), and monocyte chemoattractant protein-1 (MCP-1) levels in the second and third trimesters were measured. The mean DII scores (mean +/- SD) were -0.07 +/- 1.65 and 0.06 +/- 1.65 in the second and third trimesters, respectively. In the third trimester, IL-1beta (p = 0.039) and MCP-1 (p = 0.035) levels decreased and then increased with increasing DII scores. IL-10 concentrations decreased in pregnant women whose DII scores increased between the second and third trimesters (p = 0.011). Thiamin and vitamin C were negatively correlated with MCP-1 (beta = -0.879, and beta = -0.003) and IL-6 (beta = -0.602, and beta = -0.002) levels in the third trimester. In conclusion, the DII score had a U-shaped association with cytokine levels during the third trimester. Changes in DII scores between the second and third trimesters of pregnancy were correlated with cytokine levels during the third trimester. FAU - Cui, Tingkai AU - Cui T AUID- ORCID: 0000-0001-6366-0637 AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Jingchao AU - Zhang J AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Liu, Liyuan AU - Liu L AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Xiong, Wenjuan AU - Xiong W AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Su, Yuanyuan AU - Su Y AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Han, Yu AU - Han Y AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Gao, Lei AU - Gao L AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Qu, Zhiyi AU - Qu Z AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. AD - Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin 300070, China. LA - eng GR - 81773459/National Natural Science Foundation of China/ GR - 81973070/National Natural Science Foundation of China/ GR - 21JCQNJC01720/Tianjin Municipal Science and Technology Bureau/ GR - 2021KJ256/Tianjin Municipal Education Commission/ PT - Journal Article DEP - 20221230 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Cytokines) RN - 130068-27-8 (Interleukin-10) RN - 0 (Interleukin-6) SB - IM MH - Child MH - Female MH - Humans MH - Pregnancy MH - *Cytokines MH - East Asian People MH - Interleukin-10 MH - Interleukin-6 MH - Pregnancy Trimester, Third MH - *Pregnant Women MH - China PMC - PMC9824482 OTO - NOTNLM OT - cytokines OT - dietary inflammatory index OT - food parameters OT - pregnant women COIS- The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2023/01/09 06:00 MHDA- 2023/01/11 06:00 PMCR- 2022/12/30 CRDT- 2023/01/08 01:37 PHST- 2022/10/27 00:00 [received] PHST- 2022/12/23 00:00 [revised] PHST- 2022/12/27 00:00 [accepted] PHST- 2023/01/08 01:37 [entrez] PHST- 2023/01/09 06:00 [pubmed] PHST- 2023/01/11 06:00 [medline] PHST- 2022/12/30 00:00 [pmc-release] AID - nu15010194 [pii] AID - nutrients-15-00194 [pii] AID - 10.3390/nu15010194 [doi] PST - epublish SO - Nutrients. 2022 Dec 30;15(1):194. doi: 10.3390/nu15010194.