PMID- 36615905
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230111
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Jan 3
TI  - Red Rice Bran Extract Alleviates High-Fat Diet-Induced Non-Alcoholic Fatty Liver 
      Disease and Dyslipidemia in Mice.
LID - 10.3390/nu15010246 [doi]
LID - 246
AB  - Red rice bran extract (RRBE) is rich in phytonutrients and has been shown to have 
      anti-diabetic, anti-inflammatory, and antioxidant properties. However, its 
      anti-hepatic steatosis and anti-dyslipidemic properties have not been thoroughly 
      investigated. This study examined the aforementioned properties of RRBE, the 
      underlying mechanism by which it alleviated non-alcoholic fatty liver disease in 
      high-fat diet (HFD)-fed mice, and its major bioactive constituents. The mice were 
      divided into four groups based on their diet: (1) low-fat diet (LFD), (2) LFD 
      with high-dose RRBE (1 g/kg/day), (3) HFD, and (4) HFD with three different doses 
      of RRBE (0.25, 0.5, and 1 g/kg/day). The administration of RRBE, especially at 
      medium and high doses, significantly mitigated HFD-induced hepatosteatosis and 
      concomitantly improved the serum lipid profile. Further, RRBE modified the level 
      of expression of lipid metabolism-related genes (adipose triglyceride lipase 
      (ATGL), cluster of differentiation 36 (CD36), lipoprotein lipase (LPL), liver X 
      receptor alpha (LXRalpha), sterol regulatory element-binding protein-1c (SREBP-1c), 
      SREBP-2, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and carnitine 
      palmitoyltransferase 1A (CPT1A)) in hepatic or adipose tissues and improved the 
      expression of hepatic high-density lipoprotein cholesterol (HDL-C) 
      cmetabolism-related genes (hepatic lipase (HL) and apolipoprotein A-ǀ (ApoA-ǀ)). 
      RRBE also attenuated markers of liver injury, inflammation, and oxidative stress, 
      accompanied by a modulated expression of inflammatory (nuclear factor-kappa B 
      (NF-kappaB) and inducible nitric oxide synthase (iNOS)), pro-oxidant (p47(phox)), and 
      apoptotic (B-cell lymphoma protein 2 (Bcl-2)-associated X and Bcl-2) genes in the 
      liver. High-performance liquid chromatography analyses indicated the presence of 
      protocatechuic acid, gamma-oryzanol, vitamin E, and coenzyme Q10 in RRBE. Our data 
      indicate that RRBE alleviates HFD-induced hepatosteatosis, dyslipidemia, and 
      their pathologic complications in part by regulating the expression of key genes 
      involved in lipid metabolism, inflammation, oxidative stress, and apoptosis.
FAU - Munkong, Narongsuk
AU  - Munkong N
AUID- ORCID: 0000-0002-0097-6746
AD  - Department of Pathology, School of Medicine, University of Phayao, Phayao 56000, 
      Thailand.
FAU - Somnuk, Surasawadee
AU  - Somnuk S
AD  - Division of Nutrition for Health and Sport, Department of Sport and Health 
      Sciences, Faculty of Sport Science, Kasetsart University, Nakhon Pathom 73140, 
      Thailand.
FAU - Jantarach, Nattanida
AU  - Jantarach N
AUID- ORCID: 0000-0003-1273-7934
AD  - Applied Thai Traditional Medicine Program, School of Public Health, University of 
      Phayao, Phayao 56000, Thailand.
FAU - Ruxsanawet, Kingkarnonk
AU  - Ruxsanawet K
AD  - Applied Thai Traditional Medicine Program, School of Public Health, University of 
      Phayao, Phayao 56000, Thailand.
FAU - Nuntaboon, Piyawan
AU  - Nuntaboon P
AD  - Division of Biochemistry, School of Medical Sciences, University of Phayao, 
      Phayao 56000, Thailand.
FAU - Kanjoo, Vaiphot
AU  - Kanjoo V
AD  - Agriculture Program, School of Agriculture and Natural Resources, University of 
      Phayao, Phayao 56000, Thailand.
FAU - Yoysungnoen, Bhornprom
AU  - Yoysungnoen B
AUID- ORCID: 0000-0001-7023-3561
AD  - Division of Physiology, Department of Preclinical Science, Faculty of Medicine, 
      Thammasat University, Pathum Thani 12120, Thailand.
LA  - eng
GR  - FF64-RIB008, RD6105/Thailand Science Research and Innovation Fund/
GR  - UoE62013/University of Phayao, Thailand/
GR  - Research Group in Exercise and Aging-Associated Diseases, Faculty of Medicine, 
      Thammasat University, Thailand/
PT  - Journal Article
DEP - 20230103
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Non-alcoholic Fatty Liver Disease/drug therapy/etiology/metabolism
MH  - *Oryza
MH  - Diet, High-Fat/adverse effects
MH  - Liver/metabolism
MH  - Lipid Metabolism
MH  - Inflammation/metabolism
MH  - *Dyslipidemias/etiology/complications
MH  - Anti-Inflammatory Agents/metabolism
MH  - Mice, Inbred C57BL
PMC - PMC9824566
OTO - NOTNLM
OT  - dyslipidemia
OT  - high-fat diet
OT  - non-alcoholic fatty liver disease
OT  - obesity
OT  - red rice bran
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/09 06:00
MHDA- 2023/01/11 06:00
PMCR- 2023/01/03
CRDT- 2023/01/08 01:37
PHST- 2022/12/18 00:00 [received]
PHST- 2022/12/30 00:00 [revised]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/01/08 01:37 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2023/01/03 00:00 [pmc-release]
AID - nu15010246 [pii]
AID - nutrients-15-00246 [pii]
AID - 10.3390/nu15010246 [doi]
PST - epublish
SO  - Nutrients. 2023 Jan 3;15(1):246. doi: 10.3390/nu15010246.