PMID- 36617208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2008-076X (Print)
IS  - 2008-0778 (Electronic)
IS  - 2008-0778 (Linking)
VI  - 17
IP  - 1
DP  - 2023 Jan 1
TI  - Silver Nanoparticles Biofabricated from Cinnamomum zeylanicum Reduce IL-6, IL-18, 
      and TNF-a in Female Rats with Polycystic Ovarian Syndrome.
PG  - 80-84
LID - 252046 [pii]
LID - 10.22074/ijfs.2022.539396.1189 [doi]
AB  - Polycystic ovarian, or stein leventhal, syndrome (PCOS) is an inflammatory 
      disorder resulting in metabolic dysregulation and ovarian dysfunction as well as 
      women's infertility. Management of PCOS requires multiple approaches. This 
      experimental study was sought to assess the influence of Cinnamomum zeylanicum 
      (CZ) derived silver particles (AgNPs) on inflammatory cytokines in rats with 
      PCOS. In this experimental study, AgNPs were synthesized using CZ bark extract, 
      and characterized by the scanning electron microscope (SEM) and atomic force 
      microscope (AFM). Thirty female rats, rattus norvegicus, were grouped into five 
      groups (6 animals/group). The experimental groups were vehicle control group 
      (received 0.2 ml corn oil only), PCOS (received estradiol valerate of 4 mg/kg 
      only), PCOS group received CZ extract (200 mg/kg), PCOS group received metformin 
      (50 mg/kg) and PCOS group received AgNPs (3.53 mg/kg). After 30 days of 
      treatment, serum concentrations of tumor necrosis factor-alpha (TNF-alpha), 
      interleukins-18 (IL-18), and 6 (IL-6) were measured using ELISA. Significant 
      elevation (P<0.05) was noted in TNF-alpha, IL-6, and IL-18 levels of the PCOS group 
      when compared with findings in the control group (TNF-alpha: 250.4 +/- 32.5 vs. 164.3 +/- 
      34.4 ng/L, IL-6: 169.8 +/- 9.4 vs. 77.0 +/- 9.3 pg/ml, and IL-18: 45.9 +/- 5.5 vs. 35.3 
      +/- 4.1 ng/L). Importantly, AgNPs decreased all three inflammatory biomarkers in 
      the treated group when compared with the PCOS group (TNF-alpha: 173.9 +/- 31.2 vs. 
      250.4 +/- 32.5 ng/L, IL-6: 133.7 +/- 9.3 vs. 169.8 +/- 9.4 pg/ml, and IL-18: 36.1 +/- 6.2 
      vs. 45.9 +/- 5.5 ng/L). CZ-derived AgNPs may have an anti-inflammatory effect in 
      PCOS rats by decreasing the concentrations of inflammatory cytokines TNF-alpha, IL-6 
      and IL-18.
FAU - Alwan, Shukrya H
AU  - Alwan SH
AD  - Department of Physiology, Pharmacology and Biochemistry, College of Veterinary 
      Medicine, University of Basrah, Iraq.
AD  - Community Health Department, Technical Institute of Karbala, Al-Furat Al-Awsat 
      Technical University, Karbala, Iraq.
FAU - Al-Saeed, Mina H
AU  - Al-Saeed MH
AD  - Department of Physiology, Pharmacology and Biochemistry, College of Veterinary 
      Medicine, University of Basrah, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20230101
PL  - Iran
TA  - Int J Fertil Steril
JT  - International journal of fertility & sterility
JID - 101487941
PMC - PMC9807891
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Cinnamon
OT  - Interleukins-6
OT  - Tumor Necrosis Factor-alpha
OT  - sliver nanoparticles
EDAT- 2023/01/09 06:00
MHDA- 2023/01/09 06:01
PMCR- 2023/01/01
CRDT- 2023/01/08 01:50
PHST- 2021/09/20 00:00 [received]
PHST- 2023/01/08 01:50 [entrez]
PHST- 2023/01/09 06:00 [pubmed]
PHST- 2023/01/09 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 252046 [pii]
AID - 10.22074/ijfs.2022.539396.1189 [doi]
PST - epublish
SO  - Int J Fertil Steril. 2023 Jan 1;17(1):80-84. doi: 10.22074/ijfs.2022.539396.1189.