PMID- 36617818
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230111
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 51
IP  - 1
DP  - 2023
TI  - HLA-G in asthma and its potential as an effective therapeutic agent.
PG  - 22-29
LID - 10.15586/aei.v51i1.650 [doi]
AB  - OBJECTIVE: Asthma is a heterogeneous disease. Severity of asthma and sensitivity 
      to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a 
      wide range of functions in normal and pathological physiology. Due to its 
      powerful immune function, HLA-G participates in the pathogenesis of different 
      asthma phenotypes by regulating the activity and function of various immune 
      cells. The mechanism of HLA-G in asthma is not fully clear, and there is no 
      consensus on its mechanism in asthma. Further studies are needed to explore the 
      role of HLA-G in different phenotypes of human asthma. METHODS: Observational 
      study. RESULTS: HLA-G is an important immunomodulatory factor in asthma. Studies 
      have found different levels of HLA-G in patients with different asthma subtypes 
      and healthy controls, but other studies have come to the opposite conclusion. 
      CONCLUSION: We speculate that further study on the mechanism of HLA-G in asthma 
      pheno-types may explain some of the contradictions in current studies. Findings 
      should provide information regarding the potential of HLA-G as a novel target for 
      asthma diagnosis and treatment.
FAU - Li, Jinyan
AU  - Li J
AD  - Jilin University Second Hospital, Changchun City, Jilin Province, China.
FAU - Hao, Yuqiu
AU  - Hao Y
AD  - Jilin University Second Hospital, Changchun City, Jilin Province, China.
FAU - Li, Wei
AU  - Li W
AD  - Jilin University Second Hospital, Changchun City, Jilin Province, China.
FAU - Lv, Xuejiao
AU  - Lv X
AD  - Jilin University Second Hospital, Changchun City, Jilin Province, China.
FAU - Gao, Peng
AU  - Gao P
AD  - Jilin University Second Hospital, Changchun City, Jilin Province, China; 
      gaopeng1234@sina.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230101
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Humans
MH  - *HLA-G Antigens/genetics
MH  - *Asthma
MH  - Phenotype
MH  - Observational Studies as Topic
OTO - NOTNLM
OT  - Asthma
OT  - Asthma Subtypes
OT  - HLA-G
OT  - Inflammation
COIS- No competing interests.
EDAT- 2023/01/10 06:00
MHDA- 2023/01/11 06:00
CRDT- 2023/01/09 01:53
PHST- 2022/04/13 00:00 [received]
PHST- 2022/07/06 00:00 [accepted]
PHST- 2023/01/09 01:53 [entrez]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
AID - 10.15586/aei.v51i1.650 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2023 Jan 1;51(1):22-29. doi: 
      10.15586/aei.v51i1.650. eCollection 2023.