PMID- 36618874
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 11
IP  - 1
DP  - 2023 Jan
TI  - Endoscopic submucosal dissection using an ultrathin endoscope for superficial 
      pharyngeal cancer: a prospective feasibility study (with video).
PG  - E3-E10
LID - 10.1055/a-1968-7501 [doi]
AB  - Background and study aims  Endoscopic submucosal dissection (ESD) of pharyngeal 
      cancers with conventional endoscopes often is difficult, not only because of the 
      narrow working space, but also because endoscope maneuverability in the pharynx 
      is poor due to interference from the endotracheal tube and/or hyoid bone. 
      However, we hypothesized that those problems could possibly be resolved by use of 
      an ultrathin endoscope for ESD of superficial pharyngeal cancer. The aim of this 
      prospective interventional study was to investigate the feasibility of ESD for 
      superficial pharyngeal cancer using an ultrathin endoscope. Patients and methods  
      This feasibility study was conducted at NTT Medical Center Tokyo between June 
      2020 and September 2021, and data from a total of 20 consecutively superficial 
      pharyngeal cancers were analyzed. The primary outcome measure was the R0 
      resection rate. The ESD completion rate, en bloc resection rate, procedure time, 
      and frequency of intraoperative and postoperative adverse events (AEs) were also 
      evaluated as secondary outcome measures. Results  Data from 16 patients with 20 
      lesions were included in the analysis. All of the lesions were successfully 
      resected by ultrathin endoscope ESD, and the en bloc and R0 resection rates were 
      100 % and 85.0 % (17/20), respectively; the procedure time was 37.8 +/- 28.2 
      minutes. No intraoperative or postoperative AEs were encountered in any cases. 
      Conclusions  ESD using an ultrathin endoscope is feasible for superficial 
      pharyngeal cancers and has potential to be a safe and effective treatment option 
      for these cancers.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Muramoto, Takashi
AU  - Muramoto T
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Ohata, Ken
AU  - Ohata K
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Sakai, Eiji
AU  - Sakai E
AD  - Department of Gastroenterology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan.
FAU - Sawada, Rikimaru
AU  - Sawada R
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Takeuchi, Nao
AU  - Takeuchi N
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Inamoto, Rin
AU  - Inamoto R
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Kurebayashi, Marie
AU  - Kurebayashi M
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Takayanagi, Syunya
AU  - Takayanagi S
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Kimoto, Yoshiaki
AU  - Kimoto Y
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Ishii, Rindo
AU  - Ishii R
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Nohara, Mako
AU  - Nohara M
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Liu, Bo
AU  - Liu B
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Ono, Kohei
AU  - Ono K
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Negishi, Ryoju
AU  - Negishi R
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Minato, Yohei
AU  - Minato Y
AD  - Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan.
FAU - Chiba, Hideyuki
AU  - Chiba H
AD  - Department of Gastroenterology, Omori Red Cross Hospital, Tokyo, Japan.
FAU - Matsuhashi, Nobuyuki
AU  - Matsuhashi N
AD  - Department of Gastroenterology, NTT Medical Center Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC9812650
COIS- Competing interests The authors declare that they have no conflict of interest.
EDAT- 2023/01/10 06:00
MHDA- 2023/01/10 06:01
PMCR- 2023/01/01
CRDT- 2023/01/09 03:39
PHST- 2022/03/18 00:00 [received]
PHST- 2022/10/25 00:00 [accepted]
PHST- 2023/01/09 03:39 [entrez]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/10 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.1055/a-1968-7501 [doi]
PST - epublish
SO  - Endosc Int Open. 2023 Jan 4;11(1):E3-E10. doi: 10.1055/a-1968-7501. eCollection 
      2023 Jan.