PMID- 36618964
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2666-9560 (Electronic)
IS  - 2666-9560 (Linking)
VI  - 2
IP  - 4
DP  - 2022 Dec
TI  - Replication of neural responses to monetary incentives and exploration of 
      reward-influenced network connectivity in fibromyalgia.
LID - 100147 [pii]
LID - 10.1016/j.ynirp.2022.100147 [doi]
AB  - Neuroimaging research has begun to implicate alterations of brain reward systems 
      in chronic pain. Previously, using functional magnetic resonance imaging (fMRI) 
      and a monetary incentive delay (MID) task, Martucci et al. (2018) showed that 
      neural responses to reward anticipation and outcome are altered in fibromyalgia. 
      In the present study, we aimed to test the replicability of these altered neural 
      responses to reward in a separate fibromyalgia cohort. In addition, the present 
      study was conducted at a distinct U.S. location but involved a similar study 
      design. For the present study, 20 patients with fibromyalgia and 20 healthy 
      controls participated in MID task fMRI scan procedures and completed 
      clinical/psychological questionnaires. fMRI analyses comparing patient and 
      control groups revealed a consistent trend of main results which were largely 
      similar to the prior reported results. Specifically, in the replication 
      fibromyalgia cohort, medial prefrontal cortex (MPFC) response was reduced during 
      gain anticipation and was increased during no-loss (non-punishment) outcome 
      compared to controls. Also consistent with previous findings, the nucleus 
      accumbens response to gain anticipation did not differ in patients vs. controls. 
      Further, results from similarly-designed behavioral, correlational, and 
      exploratory analyses were complementary to previous findings. Finally, a novel 
      network-based functional connectivity analysis of the MID task fMRI data across 
      patients vs. controls implied enhanced connectivity within the default mode 
      network in participants with fibromyalgia. Together, based on replicating prior 
      univariate results and new network-based functional connectivity analyses of MID 
      task fMRI data, we provide further evidence of altered brain reward responses, 
      particularly in the MPFC response to reward outcomes, in patients with 
      fibromyalgia.
FAU - Park, Su Hyoun
AU  - Park SH
AD  - Department of Anesthesiology, Human Affect and Pain Neuroscience Laboratory, Duke 
      University School of Medicine, Durham, NC, USA.
AD  - Center for Translational Pain Medicine, Duke University Medical Center, Durham, 
      NC, USA.
FAU - Deng, Eden Z
AU  - Deng EZ
AD  - Department of Anesthesiology, Human Affect and Pain Neuroscience Laboratory, Duke 
      University School of Medicine, Durham, NC, USA.
AD  - Center for Translational Pain Medicine, Duke University Medical Center, Durham, 
      NC, USA.
FAU - Baker, Anne K
AU  - Baker AK
AD  - Department of Anesthesiology, Human Affect and Pain Neuroscience Laboratory, Duke 
      University School of Medicine, Durham, NC, USA.
AD  - Center for Translational Pain Medicine, Duke University Medical Center, Durham, 
      NC, USA.
FAU - MacNiven, Kelly H
AU  - MacNiven KH
AD  - Department of Psychology, Symbiotic Project on Affective Neuroscience Laboratory, 
      Stanford University, Stanford, CA, USA.
FAU - Knutson, Brian
AU  - Knutson B
AD  - Department of Psychology, Symbiotic Project on Affective Neuroscience Laboratory, 
      Stanford University, Stanford, CA, USA.
FAU - Martucci, Katherine T
AU  - Martucci KT
AD  - Department of Anesthesiology, Human Affect and Pain Neuroscience Laboratory, Duke 
      University School of Medicine, Durham, NC, USA.
AD  - Center for Translational Pain Medicine, Duke University Medical Center, Durham, 
      NC, USA.
LA  - eng
GR  - R00 DA040154/DA/NIDA NIH HHS/United States
GR  - R01 DA055850/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20221115
PL  - Netherlands
TA  - Neuroimage Rep
JT  - Neuroimage. Reports
JID - 9918227365206676
PMC - PMC9815752
MID - NIHMS1855871
OTO - NOTNLM
OT  - Chronic pain
OT  - Medial prefrontal cortex
OT  - Monetary incentive delay (MID) task
OT  - Nucleus accumbens
OT  - Total mood disturbance
OT  - Value
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/10 06:00
MHDA- 2023/01/10 06:01
PMCR- 2023/01/05
CRDT- 2023/01/09 03:41
PHST- 2023/01/09 03:41 [entrez]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/10 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - 100147 [pii]
AID - 10.1016/j.ynirp.2022.100147 [doi]
PST - ppublish
SO  - Neuroimage Rep. 2022 Dec;2(4):100147. doi: 10.1016/j.ynirp.2022.100147. Epub 2022 
      Nov 15.