PMID- 36620138
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230111
IS  - 2223-4292 (Print)
IS  - 2223-4306 (Electronic)
IS  - 2223-4306 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan 1
TI  - Left ventricular myocardial work index and short-term prognosis in patients with 
      light-chain cardiac amyloidosis: a retrospective cohort study.
PG  - 133-144
LID - 10.21037/qims-22-386 [doi]
AB  - BACKGROUND: Reports show that the left ventricular myocardial work index (LVMWI) 
      is a novel parameter for evaluating cardiac function. Decompensated heart failure 
      leads to a high rate of early mortality in advanced patients with light-chain 
      cardiac amyloidosis (AL-CA) and prevents them from a relatively delayed response 
      to chemotherapy. This study aimed to assess the association of the LVMWI with 
      short-term outcomes and to construct a simple model for risk stratification. 
      METHODS: A total of 79 patients with an initial diagnosis of AL-CA were included 
      in this retrospective cohort study. LVMWI was calculated by integrating brachial 
      artery cuff blood pressure and left ventricular longitudinal strain (LVLS). The 
      short-term outcome was defined as 6-month all-cause mortality. Receiver operating 
      characteristic (ROC), logistic regression, and Kaplan-Meier analysis were used in 
      this study. RESULTS: The median follow-up time was 21 months (3-36 months), and 
      23 (29%) patients died in the first 6 months. The time-dependent ROC and the area 
      under the curve (AUC) showed that the LVMWI had the best predictive potential at 
      the 6-month time point [AUC =0.805; 95% confidence interval (CI): 0.690-0.920]. A 
      bivariate prognostic model based on the LVMWI was constructed, and D-dimer showed 
      a synergistic effect with optimum predicted potential (AUC =0.877; 95% CI: 
      0.791-0.964). Kaplan-Meier analysis demonstrated that patients with two, one, and 
      none of the variates beyond the cut-off value bore a different risk of 6-month 
      all-cause mortality (accumulated mortality was 86%, 30%, 3%, respectively; 
      log-rank, P<0.001). Multivariate nested logistic regression showed that the level 
      of D-dimer provided an incremental prognostic value (Deltachi(2)=10.3; P=0.001) to the 
      value determined from New York Heart Association (NYHA) classification and the 
      LVMWI. CONCLUSIONS: The LVMWI is associated with the short-term outcome of 
      patients with AL-CA. The D-dimer test provides additional prognostic information 
      for the LVMWI.
CI  - 2023 Quantitative Imaging in Medicine and Surgery. All rights reserved.
FAU - Shi, Jiaran
AU  - Shi J
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Wu, Yakui
AU  - Wu Y
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Wu, Bifeng
AU  - Wu B
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Yu, Dongxia
AU  - Yu D
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
AD  - Department of Electrocardiogram, Zhejiang Qingchun Hospital, Hangzhou, China.
FAU - Chu, Yanan
AU  - Chu Y
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Yu, Fangcong
AU  - Yu F
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Han, Deheng
AU  - Han D
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Ye, Tianxin
AU  - Ye T
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Tao, Xinran
AU  - Tao X
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Yang, Jinxiu
AU  - Yang J
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Wang, Xingxiang
AU  - Wang X
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20221021
PL  - China
TA  - Quant Imaging Med Surg
JT  - Quantitative imaging in medicine and surgery
JID - 101577942
PMC - PMC9816762
OTO - NOTNLM
OT  - D-dimer
OT  - Light-chain cardiac amyloidosis (AL-CA)
OT  - left ventricular myocardial work index (LVMWI)
OT  - short-term outcome
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://qims.amegroups.com/article/view/10.21037/qims-22-386/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2023/01/10 06:00
MHDA- 2023/01/10 06:01
PMCR- 2023/01/01
CRDT- 2023/01/09 04:06
PHST- 2022/04/17 00:00 [received]
PHST- 2022/09/25 00:00 [accepted]
PHST- 2023/01/09 04:06 [entrez]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/10 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - qims-13-01-133 [pii]
AID - 10.21037/qims-22-386 [doi]
PST - ppublish
SO  - Quant Imaging Med Surg. 2023 Jan 1;13(1):133-144. doi: 10.21037/qims-22-386. Epub 
      2022 Oct 21.