PMID- 36621033
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230206
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 251
DP  - 2023 Feb
TI  - Exposure to volatile organic compounds and polycyclic aromatic hydrocarbons is 
      associated with the risk of non-alcoholic fatty liver disease in Korean 
      adolescents: Korea National Environmental Health Survey (KoNEHS) 2015-2017.
PG  - 114508
LID - S0147-6513(23)00012-X [pii]
LID - 10.1016/j.ecoenv.2023.114508 [doi]
AB  - Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent liver 
      diseases among adolescents. Several animal studies have suggested that volatile 
      organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) increase 
      NAFLD risk. However, few epidemiological studies have confirmed the association 
      between VOCs, PAHs and NAFLD in the general adolescent population. Therefore, we 
      analyzed 798 adolescents from the Korean National Environmental Health Survey 
      (KoNEHS), 2015-2017, to examine the associations of urinary metabolites of VOCs 
      and PAHs with serum alanine aminotransferase (ALT) activity and NAFLD prevalence. 
      We performed linear regression, logistic regression, and Bayesian kernel machine 
      regression (BKMR) to evaluate the association of urinary VOCs and PAHs 
      metabolites with ALT levels and NAFLD prevalence. After adjusting for all 
      covariates, urinary benzylmercapturic acid and 2-hydroxyfluorene levels were 
      found to increase ALT activity and NAFLD prevalence. Additionally, the BKMR 
      analyses showed a significantly positive overall effect on ALT activity and NAFLD 
      prevalence with urinary concentrations of VOCs and PAHs metabolites, with 
      2-hydroxyfluorene as the biggest contributor. Our study suggests that exposure to 
      low-level VOCs and PAHs may have a detrimental effect on NAFLD risk in 
      adolescents. Given the increasing prevalence of NAFLD in adolescents, future 
      cohort studies are confirmed to comprehend the effect of these chemicals on NAFLD 
      risk.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Choi, Yun-Hee
AU  - Choi YH
AD  - Department of Health and Safety Convergence Science, Korea University, Anam-ro 
      145, Seongbuk-gu, Seoul 02841, South Korea; BK21 FOUR R&E Center for Learning 
      Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, South 
      Korea.
FAU - Lee, Ju-Yeon
AU  - Lee JY
AD  - Department of Health and Safety Convergence Science, Korea University, Anam-ro 
      145, Seongbuk-gu, Seoul 02841, South Korea; BK21 FOUR R&E Center for Learning 
      Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, South 
      Korea.
FAU - Moon, Kyong Whan
AU  - Moon KW
AD  - BK21 FOUR R&E Center for Learning Health System, Korea University, Anam-ro 145, 
      Seongbuk-gu, Seoul 02841, South Korea; Department of Health and Environmental 
      Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, South Korea. 
      Electronic address: kwmoon@korea.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20230106
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - C7588WEA3R (2-hydroxyfluorene)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Volatile Organic Compounds)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Non-alcoholic Fatty Liver Disease/chemically induced/epidemiology
MH  - *Polycyclic Aromatic Hydrocarbons/toxicity/urine
MH  - *Volatile Organic Compounds/urine
MH  - Bayes Theorem
MH  - Environmental Health
MH  - Republic of Korea/epidemiology
MH  - Biomarkers/urine
OTO - NOTNLM
OT  - Adolescents
OT  - Korean National Environmental Health Survey (KoNEHS)
OT  - Non-alcoholic fatty liver disease (NAFLD)
OT  - Polycyclic aromatic hydrocarbons (PAHs)
OT  - Volatile organic compounds (VOCs)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/10 06:00
MHDA- 2023/02/07 06:00
CRDT- 2023/01/09 04:28
PHST- 2022/10/19 00:00 [received]
PHST- 2022/12/22 00:00 [revised]
PHST- 2023/01/02 00:00 [accepted]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2023/01/09 04:28 [entrez]
AID - S0147-6513(23)00012-X [pii]
AID - 10.1016/j.ecoenv.2023.114508 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Feb;251:114508. doi: 10.1016/j.ecoenv.2023.114508. 
      Epub 2023 Jan 6.