PMID- 36621558
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 98
DP  - 2023 Mar
TI  - Effects of simultaneous versus post exposure epigallocatechin-3-gallate treatment 
      on aluminum induced neurotoxicity in rat hippocampus: A multi-approach study.
PG  - 104061
LID - S1382-6689(23)00002-9 [pii]
LID - 10.1016/j.etap.2023.104061 [doi]
AB  - Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic 
      systems through N-methyl-D-aspartate receptors (NMDAR). This study was aimed to 
      investigate the neurotoxic effect of Al through different mechanisms in rat 
      hippocampus and to evaluate the protective role of epigallocatechin gallate 
      (EGCG), a well-known antioxidant, with simultaneous administration of Al,as well 
      as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl(3)) 
      was administered simultaneously with two different EGCG doses for 8 weeks as the 
      first part of the study.In the second part of the study, after 4 weeks of AlCl(3) 
      pre-administration, two different EGCG doses were also administered during four 
      additional weeks as post-treatment.Al administration led to oxidative stress and 
      increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were 
      down-regulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG 
      treatment has shown a better neuroprotective effect in terms of these mechanisms 
      and represents novel approach for the prevention of neurodegenerative diseases 
      likely to be induced by Al.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Palabiyik-Yuceli K, Saziye Sezin
AU  - Palabiyik-Yuceli K SS
AD  - Ataturk University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 
      Erzurum, 25240, Turkey; Clinical Research, Development and Design Application and 
      Research Center, Ataturk University, Erzurum, Turkey. Electronic address: 
      spalabiyik@atauni.edu.tr.
FAU - Zeybek, Naciye Dilara
AU  - Zeybek ND
AD  - Hacettepe University, Faculty of Medicine, Department of Histology and 
      Embryology, Ankara, Turkey.
FAU - Cinar, Irfan
AU  - Cinar I
AD  - Department of Pharmacology, Faculty of Medicine, Kastamonu University, 37000, 
      Kastamonu, Turkey.
FAU - Akpinar, Erol
AU  - Akpinar E
AD  - Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 
      Erzurum, Turkey.
FAU - Bahador Zirh, Elham
AU  - Bahador Zirh E
AD  - TOBB University of Economics and Technology, Faculty of Medicine, Department of 
      Histology and Embryology, Ankara, Turkey.
FAU - Si Pahi, Hande
AU  - Si Pahi H
AD  - Yeditepe University, Faculty of Pharmacy, Department of Pharmaceutical 
      Toxicology, Istanbul, Turkey.
FAU - Halici, Zekai
AU  - Halici Z
AD  - Clinical Research, Development and Design Application and Research Center, 
      Ataturk University, Erzurum, Turkey; Ataturk University, Faculty of Medicine, 
      Department of Pharmacology, 25240 Erzurum, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230106
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - CPD4NFA903 (Aluminum)
RN  - 0 (Antioxidants)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - 8R1V1STN48 (Catechin)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Aluminum/toxicity
MH  - Antioxidants/pharmacology
MH  - Rats, Wistar
MH  - Acetylcholinesterase/metabolism
MH  - Hippocampus
MH  - *Neurotoxicity Syndromes/drug therapy
MH  - Oxidative Stress
MH  - *Catechin/pharmacology/therapeutic use
MH  - *Neuroprotective Agents/pharmacology
OTO - NOTNLM
OT  - Aluminum
OT  - Epigallocatechin gallate
OT  - NMDAR
OT  - Neurotoxicity
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/10 06:00
MHDA- 2023/03/08 06:00
CRDT- 2023/01/09 04:56
PHST- 2022/02/09 00:00 [received]
PHST- 2022/12/28 00:00 [revised]
PHST- 2023/01/04 00:00 [accepted]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2023/01/09 04:56 [entrez]
AID - S1382-6689(23)00002-9 [pii]
AID - 10.1016/j.etap.2023.104061 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2023 Mar;98:104061. doi: 10.1016/j.etap.2023.104061. 
      Epub 2023 Jan 6.