PMID- 36622665
OWN - NLM
STAT- MEDLINE
DCOM- 20230111
LR  - 20230111
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 42
DP  - 2023 Jan-Dec
TI  - Follow-up of patients with a 5-year survival after paraquat poisoning using 
      computed tomography images and spirometry.
PG  - 9603271221150243
LID - 10.1177/09603271221150243 [doi]
AB  - OBJECTIVES: The study aimed to examine long-term survival of patients with acute 
      paraquat poisoning using computed tomography (CT) images and spirometry. METHODS: 
      A total of 36 patients with long-term survival after paraquat poisoning were 
      followed-up and divided into mild (11 patients), moderate (17 patients), and 
      severe (8 patients) paraquat poisoning groups. Differences among the groups were 
      compared using clinical indicators, such as peripheral capillary oxygen 
      saturation, arterial partial pressure of oxygen and 6-min walk test (6-MWT), 
      chest CT, spirometry, and serum immunoglobulin E (IgE). RESULTS: The 6-MWT 
      distance was significantly shorter in the severe paraquat poisoning group than 
      that in the mild and moderate paraquat poisoning groups. In the mild paraquat 
      poisoning group, CT revealed no obvious lung injury, and spirometry showed normal 
      lung function in most patients. In moderate or severe paraquat poisoning group, 
      CT images showed fibrotic lesions as cord-like high-density shadows, 
      reticulations, and honeycombs. In addition, other pulmonary changes, including 
      bronchiectasis, increased lung transparency, and pulmonary bullae, were 
      discovered. In moderate or severe paraquat poisoning group, obvious obstructive 
      ventilation dysfunction with slight restrictive and diffuse impairment were 
      observed in some patients, with positive bronchial relaxation test and high serum 
      IgE level. CONCLUSION: In the long-term follow-up, patients with severe paraquat 
      poisoning showed the lowest exercise endurance. In moderate or severe paraquat 
      poisoning group, CT images revealed diversified changes, not only dynamic 
      evolution of pulmonary fibrosis process, but also signs of bronchiectasis, and 
      chronic obstructive pulmonary disease. Some patients with moderate or severe 
      paraquat poisoning developed obstructive ventilatory dysfunction with airway 
      hyperresponsiveness.
FAU - Fan, Lu
AU  - Fan L
AUID- ORCID: 0000-0002-7446-6730
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Wang, Xuejie
AU  - Wang X
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Lv, Tianyi
AU  - Lv T
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Xue, Fei
AU  - Xue F
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Wu, Benhe
AU  - Wu B
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Ma, Aiwen
AU  - Ma A
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
FAU - Lu, Mingfeng
AU  - Lu M
AUID- ORCID: 0000-0001-8019-7752
AD  - Clinical Medical College, 38043Yangzhou University, Yangzhou, P. R. China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - PLG39H7695 (Paraquat)
SB  - IM
MH  - Humans
MH  - *Paraquat
MH  - Follow-Up Studies
MH  - Lung/pathology
MH  - *Bronchiectasis
MH  - Spirometry
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Computed tomography
OT  - airway hyperresponsiveness
OT  - follow-up
OT  - paraquat poisoning
OT  - spirometry
EDAT- 2023/01/10 06:00
MHDA- 2023/01/12 06:00
CRDT- 2023/01/09 11:33
PHST- 2023/01/09 11:33 [entrez]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/12 06:00 [medline]
AID - 10.1177/09603271221150243 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2023 Jan-Dec;42:9603271221150243. doi: 
      10.1177/09603271221150243.