PMID- 36623828
OWN - NLM
STAT- MEDLINE
DCOM- 20230208
LR  - 20230208
IS  - 2567-6407 (Electronic)
IS  - 0029-5566 (Linking)
VI  - 62
IP  - 1
DP  - 2023 Feb
TI  - Adverse events unlikely after fine-needle aspiration biopsies of thyroid nodules 
      in patients on low-dose aspirin: a prospective controlled systematic single 
      center analysis.
PG  - 34-37
LID - 10.1055/a-1972-9372 [doi]
AB  - AIM: Our aim was to test the assertion that in terms of rate or severity level, 
      adverse events (AEs) after fine-needle aspiration biopsies (FNABs) of thyroid 
      nodules are unfazed by daily low-dose (100 mg) aspirin (acetylsalicylic acid, 
      ASA) intake. METHODS: We selected 268 patients for study, grouped as ASA-treated 
      (P(ASA), n=78) or control (P(Ctrl), n=190) subjects. Controls received no 
      antithrombotic medication. AE rates and severities were then analyzed based on 
      patient- and nodule-related factors. We also compared group rates of 
      non-diagnostic cytology results. RESULTS: AEs arising after FNABs (P(ASA), 5%; 
      P(Ctrl), 8%) did not differ significantly by group in rate (p=0.4873) or severity 
      level (p=0.3399). All were classifiable as minor incidents, none warranting any 
      intervention. CONCLUSIONS: The data from the present study suggest, AEs after 
      FNABs of thyroid nodules seldom occur and qualify as minor incidents. Such 
      procedures may be safely conducted in patients taking daily low-dose ASA. There 
      is no evidence to support preemptive therapeutic withdrawal.
CI  - Thieme. All rights reserved.
FAU - Cordes, Michael
AU  - Cordes M
AD  - Nuklearmedizin, Radiologisch-Nuklearmedizinisches Zentrum, Nuremberg, Germany.
AD  - Nuklearmedizinische Klinik, Universitatsklinikum Erlangen, Erlangen, Germany.
FAU - Gotz, Theresa Ida
AU  - Gotz TI
AD  - Department of Industrial Engineering and Health, Technical University 
      Amberg-Weiden, Institute of Medical Engineering, Weiden, Germany.
FAU - Kuwert, Torsten
AU  - Kuwert T
AD  - Nuklearmedizinische Klinik, Universitatsklinikum Erlangen, Erlangen, Germany.
FAU - Schmidkonz, Christian
AU  - Schmidkonz C
AD  - Nuklearmedizinische Klinik, Universitatsklinikum Erlangen, Erlangen, Germany.
AD  - Department of Industrial Engineering and Health, Technical University 
      Amberg-Weiden, Institute of Medical Engineering, Weiden, Germany.
LA  - eng
PT  - Journal Article
TT  - Unwahrscheinliches Auftreten von unerwunschten Ereignissen nach Feinnadelbiopsien 
      von Strumaknoten bei Patienten mit einer Niedrigdosismedikation von Aspirin: eine 
      prospektive, kontrollierte und systematische Single-Center-Studie.
DEP - 20230109
PL  - Germany
TA  - Nuklearmedizin
JT  - Nuklearmedizin. Nuclear medicine
JID - 7609387
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Humans
MH  - *Thyroid Nodule/pathology
MH  - Biopsy, Fine-Needle/adverse effects/methods
MH  - Prospective Studies
MH  - Aspirin/adverse effects
MH  - *Thyroid Neoplasms/pathology
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/01/10 06:00
MHDA- 2023/02/09 06:00
CRDT- 2023/01/09 19:52
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2023/01/09 19:52 [entrez]
AID - 10.1055/a-1972-9372 [doi]
PST - ppublish
SO  - Nuklearmedizin. 2023 Feb;62(1):34-37. doi: 10.1055/a-1972-9372. Epub 2023 Jan 9.