PMID- 36624073
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230331
IS  - 1881-1361 (Electronic)
IS  - 0287-4547 (Linking)
VI  - 42
IP  - 2
DP  - 2023 Mar 30
TI  - Platelet-rich fibrin combined with new bone graft material for mandibular defect 
      repair: A in vivo study on rabbits.
PG  - 241-247
LID - 10.4012/dmj.2022-076 [doi]
AB  - Insufficient bone mass is still a difficult point to be solved in oral 
      implantation, so new bone graft materials are continuously researched and 
      discussed in clinical practice in order to obtain better bone augmentation. In 
      order to explore whether platelet-rich fibrin (PRF) can promote the formation of 
      new bone in mineralized collagen (MC), MC/PRF and pure MC were implanted into the 
      bilateral mandibular defect model in rabbits, respectively. Micro-CT scan and 
      histological evaluation of the target area at 4, 8, and 12 weeks after operation. 
      The results of Micro-CT three-dimensional reconstruction analysis showed that the 
      ratio of bone volume to total volume (BV/TV), trabecular bone number (Tb.N), 
      trabecular bone thickness (Tb.Th) and trabecular bone separation (Tb.Sp) and 
      residual material volume fraction (RMVF) in the MC/PRF group were better than 
      those in the MC group (p<0.05). The results of HE and Masson staining showed that 
      the new bone formation and material degradation rate of the MC/PRF group were 
      better than those of the MC group. The results suggest that PRF can accelerate 
      the formation of new bone in MC, and provide new ideas for the clinical 
      application of new bone graft materials.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
FAU - Cao, Can
AU  - Cao C
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
FAU - Li, Jun
AU  - Li J
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
FAU - Liu, Chi
AU  - Liu C
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
FAU - Mi, Ketong
AU  - Mi K
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
FAU - Zhang, Xiaodong
AU  - Zhang X
AD  - Department of Stomatology, The General Hospital of the Northern Theater Command 
      of the Chinese People's Liberation Army.
LA  - eng
PT  - Journal Article
DEP - 20230107
PL  - Japan
TA  - Dent Mater J
JT  - Dental materials journal
JID - 8309299
RN  - 9007-34-5 (Collagen)
MH  - Animals
MH  - Rabbits
MH  - *Platelet-Rich Fibrin
MH  - Bone Density
MH  - Collagen
MH  - X-Ray Microtomography
MH  - Bone Regeneration
OTO - NOTNLM
OT  - Bone augmentation
OT  - Bone graft substitute material
OT  - Mineralized collagen
OT  - Platelet-rich fibrin
EDAT- 2023/01/10 06:00
MHDA- 2023/03/31 06:42
CRDT- 2023/01/09 22:53
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/01/10 06:00 [pubmed]
PHST- 2023/01/09 22:53 [entrez]
AID - 10.4012/dmj.2022-076 [doi]
PST - ppublish
SO  - Dent Mater J. 2023 Mar 30;42(2):241-247. doi: 10.4012/dmj.2022-076. Epub 2023 Jan 
      7.