PMID- 36624973
OWN - NLM
STAT- MEDLINE
DCOM- 20240227
LR  - 20240227
IS  - 1369-1619 (Electronic)
IS  - 0960-3123 (Linking)
VI  - 34
IP  - 2
DP  - 2024 Feb
TI  - Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat 
      via inhibition of ACE activity and MAPK pathway.
PG  - 755-766
LID - 10.1080/09603123.2023.2166023 [doi]
AB  - This study investigates the protective role of Hispidulin on acute respiratory 
      distress syndrome (ARDS) in rats. Rats were divided into three groups: control, 
      ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with 
      oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. 
      Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases 
      (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), 
      and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis 
      factor-alpha (TNF-alpha) expression was described by RT-qPCR. Caspase-3 
      immunostaining was performed to evaluate apoptosis. Compared with the model 
      group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO 
      levels, and TNF-alpha expression in the ARDS+ Hispidulin group. Moreover, reduced 
      caspase-3 immunoreactivity and activity of ACE were detected in the 
      Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act 
      through inhibition of the ACE activity and then regulation of inflammatory 
      cytokine level and alteration of apoptosis.
FAU - Koc, Kubra
AU  - Koc K
AUID- ORCID: 0000-0001-6208-165X
AD  - Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.
FAU - Ozek, Nihal Simsek
AU  - Ozek NS
AUID- ORCID: 0000-0002-7326-5670
AD  - Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.
AD  - East Anatolian High Technology Research and Application Center (DAYTAM), Ataturk 
      University, Erzurum, Turkey.
FAU - Aysin, Ferhunde
AU  - Aysin F
AUID- ORCID: 0000-0003-1971-8031
AD  - Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.
AD  - East Anatolian High Technology Research and Application Center (DAYTAM), Ataturk 
      University, Erzurum, Turkey.
FAU - Demir, Ozlem
AU  - Demir O
AUID- ORCID: 0000-0001-9852-8839
AD  - Department of Histology and Embryology, Faculty of Medicine, Erzincan Binali 
      Yildirim University, Erzincan, Turkey.
FAU - Yilmaz, Asli
AU  - Yilmaz A
AUID- ORCID: 0000-0001-7874-5641
AD  - Department of Molecular Biology and Genetics, Faculty of Science, Ataturk 
      University, Erzurum, Turkey.
FAU - Yilmaz, Mehmet
AU  - Yilmaz M
AUID- ORCID: 0000-0003-2687-9167
AD  - Department of Nanoscience and Nanoengineering, Ataturk University, Erzurum, 
      Turkey.
FAU - Geyikoglu, Fatime
AU  - Geyikoglu F
AUID- ORCID: 0000-0003-2488-1757
AD  - Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.
FAU - Erol, Huseyin Serkan
AU  - Erol HS
AUID- ORCID: 0000-0002-9121-536X
AD  - Department of Biochemistry, Kastamonu University, Faculty of Veterinary Medicine, 
      Kastamonu, TURKEY.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - England
TA  - Int J Environ Health Res
JT  - International journal of environmental health research
JID - 9106628
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - N7F61604C2 (hispidulin)
RN  - EC 3.4.22.- (Caspase 3)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Flavones)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Lung
MH  - Mitogen-Activated Protein Kinases/metabolism/pharmacology
MH  - Oleic Acid/toxicity
MH  - Caspase 3
MH  - Interleukin-8
MH  - Tumor Necrosis Factor-alpha/metabolism/pharmacology
MH  - *Respiratory Distress Syndrome/pathology
MH  - *Flavones
OTO - NOTNLM
OT  - ACE activity
OT  - Hispidulin
OT  - lung injury with ARDS
EDAT- 2023/01/11 06:00
MHDA- 2024/02/27 06:44
CRDT- 2023/01/10 02:04
PHST- 2024/02/27 06:44 [medline]
PHST- 2023/01/11 06:00 [pubmed]
PHST- 2023/01/10 02:04 [entrez]
AID - 10.1080/09603123.2023.2166023 [doi]
PST - ppublish
SO  - Int J Environ Health Res. 2024 Feb;34(2):755-766. doi: 
      10.1080/09603123.2023.2166023. Epub 2023 Jan 9.