PMID- 36625929
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 261
IP  - 6
DP  - 2023 Jun
TI  - Automated macular segmentation can distinguish glaucomatous from compressive 
      optic neuropathy.
PG  - 1701-1712
LID - 10.1007/s00417-022-05962-6 [doi]
AB  - PURPOSE: To compare macular damage in glaucomatous optic neuropathy (GON) and 
      compressive optic neuropathy (CON) and assess its diagnostic accuracy in 
      distinguishing between diseases. METHODS: Observational, cross-sectional, 
      single-center study. Patients with GON, CON, and healthy controls were included 
      according to the eligibility criteria. An automated spectral-domain optical 
      coherence tomography (SD-OCT) algorithm was used to segment the circumpapilary 
      retinal nerve fiber layer (cpRNFL) and macula. The layer thickness was measured 
      in each sector according to the Early Treatment Diabetic Retinopathy Study and 
      the 6-sector Garway-Heath-based grids. Data was compared across all study groups, 
      and the significance level was set at 0.05. RESULTS: Seventy-five eyes of 75 
      participants, 25 with GON, 25 with CON, and 25 healthy controls (CG), were 
      included. Macular thickness was diminished in the ganglion cell complex of GON 
      and CON patients compared to CG (p<0.05). The best Garway-Heath-based grid 
      parameters for distinguishing GON and CON were the nasal-inferior (NI) and 
      nasal-superior sectors and the NI/temporal inferior (TI) damage ratios in the 
      macular ganglion cell (mGCL) and inner plexiform (IPL) layers. Moreover, the 
      combination of the NI sector and NI/TI damage ratios in both layers had higher 
      discriminative power (AUC 0.909; 95% CI 0.830-0.988; p<0.001) than combining 
      parameters in each layer separately. CONCLUSION: Our findings suggest that the 
      evaluation of macular segmented layers damage by SD-OCT may be a helpful add-on 
      tool in the differential diagnosis between GON and CON.
CI  - (c) 2023. The Author(s).
FAU - Soares, Ricardo Machado
AU  - Soares RM
AUID- ORCID: 0000-0002-2998-6251
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal. ricardo.machado.soares@chvng.min-saude.pt.
FAU - Braga, Joana Figueiredo
AU  - Braga JF
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal.
FAU - da Silva Fernandes, Joana
AU  - da Silva Fernandes J
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal.
FAU - Ferreira, Catarina Cunha
AU  - Ferreira CC
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal.
FAU - Ribeiro, Ligia
AU  - Ribeiro L
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal.
FAU - Alves, Helio
AU  - Alves H
AD  - Department of Biomedicine - Faculty of Medicine of University of Porto, Porto, 
      Portugal.
FAU - Meira, Dalia
AU  - Meira D
AD  - Department of Ophthalmology - Centro Hospitalar de Vila Nova de Gaia e Espinho 
      EPE, Porto, Portugal.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230110
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Humans
MH  - *Optic Disk
MH  - Cross-Sectional Studies
MH  - Retinal Ganglion Cells
MH  - Nerve Fibers
MH  - *Optic Nerve Diseases/diagnosis
MH  - *Glaucoma/diagnosis
MH  - *Macula Lutea
MH  - Tomography, Optical Coherence/methods
PMC - PMC10198839
OTO - NOTNLM
OT  - Compressive optic neuropathy
OT  - Glaucomatous optic neuropathy
OT  - Hypothalamic neoplasms
OT  - Optic atrophy
OT  - Optical coherence tomography
COIS- The authors declare no competing interests.
EDAT- 2023/01/11 06:00
MHDA- 2023/05/22 06:42
PMCR- 2023/01/10
CRDT- 2023/01/10 11:16
PHST- 2022/09/06 00:00 [received]
PHST- 2022/12/24 00:00 [accepted]
PHST- 2022/11/30 00:00 [revised]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/01/11 06:00 [pubmed]
PHST- 2023/01/10 11:16 [entrez]
PHST- 2023/01/10 00:00 [pmc-release]
AID - 10.1007/s00417-022-05962-6 [pii]
AID - 5962 [pii]
AID - 10.1007/s00417-022-05962-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2023 Jun;261(6):1701-1712. doi: 
      10.1007/s00417-022-05962-6. Epub 2023 Jan 10.