PMID- 36627064
OWN - NLM
STAT- MEDLINE
DCOM- 20230223
LR  - 20230223
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 22
IP  - 3
DP  - 2023 Mar
TI  - Longitudinal monitoring of circulating immune cell phenotypes in anti-neutrophil 
      cytoplasmic antibody-associated vasculitis.
PG  - 103271
LID - S1568-9972(23)00005-8 [pii]
LID - 10.1016/j.autrev.2023.103271 [doi]
AB  - Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a necrotizing 
      multiorgan autoimmune disease that affects small- to medium-sized blood vessels. 
      Despite the improvements in treatments, half of the patients with AAV still 
      experience disease relapses. In this review, we focus on peripheral leukocyte 
      properties and phenotypes in patients with AAV. In particular, we explore 
      longitudinal changes in circulating immune cell phenotypes during the active 
      phase of the disease and treatment. The numbers and phenotypes of leukocytes in 
      peripheral blood were differs between AAV and healthy controls, AAV in active 
      versus inactive phase, AAV in treatment responders versus non-responders, and AAV 
      with and without severe infection. Therefore, biomarkers detected in peripheral 
      blood immune cells may be useful for longitudinal monitoring of disease activity 
      in AAV.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Matsumoto, Kotaro
AU  - Matsumoto K
AD  - Division of Rheumatology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan. Electronic address: aa615119@keio.jp.
FAU - Suzuki, Katsuya
AU  - Suzuki K
AD  - Division of Rheumatology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan.
FAU - Yasuoka, Hidekata
AU  - Yasuoka H
AD  - Division of Rheumatology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan; Division of Rheumatology, Department of Internal 
      Medicine, Fujita Health University School of Medicine, Aichi, Japan.
FAU - Hirahashi, Junichi
AU  - Hirahashi J
AD  - Center for General Medicine Education, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Yoshida, Hiroto
AU  - Yoshida H
AD  - Chugai Pharmaceutical Co. Ltd., Kanagawa, Japan.
FAU - Magi, Mayu
AU  - Magi M
AD  - Chugai Pharmaceutical Co. Ltd., Kanagawa, Japan.
FAU - Noguchi-Sasaki, Mariko
AU  - Noguchi-Sasaki M
AD  - Chugai Pharmaceutical Co. Ltd., Kanagawa, Japan.
FAU - Kaneko, Yuko
AU  - Kaneko Y
AD  - Division of Rheumatology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan.
FAU - Takeuchi, Tsutomu
AU  - Takeuchi T
AD  - Division of Rheumatology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230107
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Biomarkers)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy
MH  - Biomarkers
MH  - *Extracellular Traps
MH  - B-Lymphocytes
MH  - Phenotype
MH  - Antibodies, Antineutrophil Cytoplasmic
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - Gene expression
OT  - Immuno-phenotyping
COIS- Declaration of Competing Interest KM, KS, HYa, and JH declare no conflicts of 
      interest. HYo, MM, and MN-S were employees of Chugai Pharmaceutical Co., Ltd. YK 
      and TT received research grants from Chugai Pharmaceutical Co., Ltd.
EDAT- 2023/01/11 06:00
MHDA- 2023/02/25 06:00
CRDT- 2023/01/10 19:20
PHST- 2022/12/10 00:00 [received]
PHST- 2023/01/05 00:00 [accepted]
PHST- 2023/01/11 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2023/01/10 19:20 [entrez]
AID - S1568-9972(23)00005-8 [pii]
AID - 10.1016/j.autrev.2023.103271 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2023 Mar;22(3):103271. doi: 10.1016/j.autrev.2023.103271. Epub 
      2023 Jan 7.