PMID- 36627067
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20230403
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 41
DP  - 2023 Mar
TI  - Evaluation of corneal topographic parameters in patients with psoriasis.
PG  - 103280
LID - S1572-1000(23)00009-1 [pii]
LID - 10.1016/j.pdpdt.2023.103280 [doi]
AB  - BACKGROUND: To evaluate corneal topographic parameters in patients with 
      psoriasis. METHODS: This prospective, cross-sectional study included 50 right 
      eyes of 50 patients with psoriasis and 50 right eyes of 50 age- and sex-matched 
      healthy individuals. Detailed dermatological and ophthalmological examinations 
      were performed in all cases. Noninvasive tear break-up time (NIBUT), meibography, 
      keratometry values, and high-order corneal aberrations (HOAs) were obtained using 
      corneal topography and compared to healthy subjects. These values were also 
      evaluated according to anti-tumor necrosis factor alpha (anti-TNF-alpha) use, the 
      Psoriasis Area and Severity Index (PASI) score, psoriasis duration, and patient 
      age. The chi-square test, Mann-Whitney U test, and Pearson correlation test were 
      used for statistical assessment. RESULTS: Lower NIBUT and higher meibomian gland 
      loss (MGL) were detected in psoriasis patients compared to healthy controls. 
      There were no significant differences between the groups in terms of corneal 
      HOAs. Higher MGL was detected in patients using anti-TNF-alpha than in patients not 
      using it. A positive correlation was found among topographic parameters, 
      especially between PASI score and the patient's age. No correlations were found 
      between the disease duration and the other parameters. CONCLUSION: NIBUT and MGL 
      are more common in psoriasis patients than in healthy subjects. The relationship 
      between anti-TNF-alpha use, PASI score, patient age, and corneal parameters should be 
      considered in the follow-up and treatment of ocular findings in psoriasis 
      patients.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Agackesen, Anil
AU  - Agackesen A
AD  - Kartal Dr. Lutfi Kirdar City Hospital, Ophthalmology Clinic, Istanbul, Turkey. 
      Electronic address: anilagackesen@gmail.com.
FAU - Gunaydin, Nesrin Tutas
AU  - Gunaydin NT
AD  - Kartal Dr. Lutfi Kirdar City Hospital, Ophthalmology Clinic, Istanbul, Turkey.
FAU - Goktas, Eren
AU  - Goktas E
AD  - Medibafra Private Hospital, Ophtalmology Clinic, Bafra, Turkey.
FAU - Aslan, Abdurrahman
AU  - Aslan A
AD  - Kartal Dr. Lutfi Kirdar City Hospital, Dermatology Clinic, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230107
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Tumor Necrosis Factor Inhibitors)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - Corneal Topography
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Tumor Necrosis Factor Inhibitors/therapeutic use
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents/therapeutic use
MH  - Tumor Necrosis Factor-alpha
MH  - *Psoriasis/drug therapy
OTO - NOTNLM
OT  - Anti-TNF- alpha
OT  - Corneal aberrations
OT  - Meibography
OT  - Noninvasive tear break up time
OT  - PASI score, Psoriasis
OT  - Scheimpflug imaging
EDAT- 2023/01/11 06:00
MHDA- 2023/04/03 06:41
CRDT- 2023/01/10 19:20
PHST- 2022/08/29 00:00 [received]
PHST- 2022/12/23 00:00 [revised]
PHST- 2023/01/04 00:00 [accepted]
PHST- 2023/04/03 06:41 [medline]
PHST- 2023/01/11 06:00 [pubmed]
PHST- 2023/01/10 19:20 [entrez]
AID - S1572-1000(23)00009-1 [pii]
AID - 10.1016/j.pdpdt.2023.103280 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Mar;41:103280. doi: 
      10.1016/j.pdpdt.2023.103280. Epub 2023 Jan 7.