PMID- 36629078
OWN - NLM
STAT- MEDLINE
DCOM- 20230112
LR  - 20230113
IS  - 2260-1341 (Print)
IS  - 2273-4309 (Electronic)
IS  - 2260-1341 (Linking)
VI  - 12
IP  - 1
DP  - 2023
TI  - Association of Intrinsic Capacity with Frailty, Physical Fitness and Adverse 
      Health Outcomes in Community-Dwelling Older Adults.
PG  - 7-15
LID - 10.14283/jfa.2022.28 [doi]
AB  - BACKGROUND: Intrinsic capacity (IC) and frailty are complementary in advancing 
      disability prevention through maintaining functionality. OBJECTIVES: We examined 
      the relationship between IC and frailty status at baseline and 1-year, and 
      evaluated if IC decline predicts frailty onset among robust older adults. The 
      secondary objectives investigated associations between IC, physical fitness and 
      health-related outcomes. DESIGN: Prospective cohort study. SETTING: 
      Community-based assessments. PARTICIPANTS: Older adults aged>55 years, who were 
      independent in ambulation (walking aids permitted). MEASUREMENTS: 5 domains of IC 
      were assessed at baseline: locomotion (Short Physical Performance Battery, 
      6-minute walk test), vitality (nutritional status, muscle mass), sensory 
      (self-reported hearing and vision), cognition (self-reported memory, age- and 
      education adjusted cognitive performance), psychological (Geriatric Depression 
      Scale-15, self-reported anxiety/ depression). Composite IC (0-10) was calculated, 
      with higher scores representing greater IC. Frailty status was based on modified 
      Fried criteria, with frailty progression defined as incremental Fried score at 
      1-year. RESULTS: 809 participants (67.6+6.8 years) had complete data for all 5 IC 
      domains. 489 (60.4%) participants were robust but only 213 (26.3%) had no decline 
      in any IC domain. Pre-frail and frail participants were more likely to exhibit 
      decline in all 5 IC domains (p<0.05), with decremental composite IC [9 (8-9), 8 
      (6-9), 5.5 (4-7.5), p<0.001] across robust, prefrail and frail. IC was 
      significantly associated with fitness performance, independent of age and gender. 
      Higher composite IC reduced risk for frailty progression (OR=0.62, 95% CI 
      0.48-0.80), and reduced frailty onset among robust older adults (OR=0.53, 95% CI 
      0.37-0.77), independent of age, comorbidities and social vulnerability. 
      Participants with higher IC were less likely to experience health deterioration 
      (OR=0.70, 95% CI 0.58-0.83), falls (OR=0.76, 95% CI 0.65-0.90) and functional 
      decline (OR=0.64, 95% CI 0.50-0.83) at 1-year. CONCLUSION: Declining IC may 
      present before frailty becomes clinically manifest, increasing risk for poor 
      outcomes. Monitoring of IC domains potentially facilitates personalized 
      interventions to avoid progressive frailty.
FAU - Tay, L
AU  - Tay L
AD  - Dr Laura Tay, Geriatric Medicine, Department of General Medicine, Sengkang 
      General Hospital, 110 Sengkang East Way, Singapore 544886, Phone: +65-69302910, 
      Email: laura.tay.b.g@singhealth.com.sg.
FAU - Tay, E-L
AU  - Tay EL
FAU - Mah, S M
AU  - Mah SM
FAU - Latib, A
AU  - Latib A
FAU - Koh, C
AU  - Koh C
FAU - Ng, Y-S
AU  - Ng YS
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Frailty Aging
JT  - The Journal of frailty & aging
JID - 101604797
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Frailty/diagnosis/epidemiology/complications
MH  - Independent Living
MH  - Frail Elderly/psychology
MH  - Prospective Studies
MH  - Geriatric Assessment
MH  - Physical Fitness
MH  - Outcome Assessment, Health Care
PMC - PMC8966852
OTO - NOTNLM
OT  - Intrinsic capacity
OT  - elderly
OT  - fitness
OT  - frailty
COIS- All the authors have no conflict of interest or financial disclosure of note.
EDAT- 2023/01/12 06:00
MHDA- 2023/01/13 06:00
PMCR- 2022/03/30
CRDT- 2023/01/11 06:23
PHST- 2023/01/11 06:23 [entrez]
PHST- 2023/01/12 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2022/03/30 00:00 [pmc-release]
AID - 137 [pii]
AID - 10.14283/jfa.2022.28 [doi]
PST - ppublish
SO  - J Frailty Aging. 2023;12(1):7-15. doi: 10.14283/jfa.2022.28.