PMID- 36629094 OWN - NLM STAT- MEDLINE DCOM- 20230405 LR - 20230511 IS - 1758-1052 (Electronic) IS - 0956-4624 (Linking) VI - 34 IP - 5 DP - 2023 Apr TI - Treatment management of M. simiae infection complicated by severe immune reconstitution syndrome in two patients living with HIV. PG - 355-360 LID - 10.1177/09564624221151090 [doi] AB - Nontuberculosis mycobacterium are increasingly being identified as sources of disseminated infections in immunocompromised patients. These infections can be challenging to identify and treat due complexities of diagnosis and inherent resistance to many medications. We present two cases of patients with human immunodeficiency virus who had Mycobacterium simiae infections, complicated by immune reconstruction inflammatory syndrome (IRIS). We also present a review of the English literature surrounding the disease, including reported resistance patterns to antimicrobial therapy, which can be highly variable. FAU - Rodriguez, Chelsea AU - Rodriguez C AD - Department of Pharmacy, 21764University of New Mexico Hospitals, Albuquerque, NM, USA. FAU - Salas, Natalie Mariam AU - Salas NM AUID- ORCID: 0000-0002-8795-3431 AD - Department of Internal Medicine, Division of Infectious Diseases, 1104University of New Mexico Hospitals, Albuquerque, NM, USA. FAU - Begay-Bruno, Matthew AU - Begay-Bruno M AD - Department of Pharmacy Practice and Administrative Sciences, 15520University of New Mexico College of Pharmacy, Albuquerque, NM, USA. FAU - Brett, Meghan AU - Brett M AD - Department of Internal Medicine, Division of Infectious Diseases, 1104University of New Mexico Hospitals, Albuquerque, NM, USA. FAU - Byrd, Tom F AU - Byrd TF AD - Department of Internal Medicine, Division of Infectious Diseases, 1104University of New Mexico Hospitals, Albuquerque, NM, USA. FAU - Ruan, Lucy AU - Ruan L AD - Department of Internal Medicine, Division of Infectious Diseases, 1104University of New Mexico Hospitals, Albuquerque, NM, USA. FAU - Jakeman, Bernadette AU - Jakeman B AUID- ORCID: 0000-0002-5849-9110 AD - Department of Pharmacy Practice and Administrative Sciences, 15520University of New Mexico College of Pharmacy, Albuquerque, NM, USA. LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20230111 PL - England TA - Int J STD AIDS JT - International journal of STD & AIDS JID - 9007917 RN - 0 (Anti-Infective Agents) SB - IM MH - Humans MH - HIV MH - *Immune Reconstitution Inflammatory Syndrome/complications/diagnosis/drug therapy MH - *Mycobacterium Infections MH - *Anti-Infective Agents/therapeutic use MH - *HIV Infections/complications/drug therapy OTO - NOTNLM OT - Immune reconstitution inflammatory syndrome OT - Mycobacterium simiae OT - human immunodeficiency virus EDAT- 2023/01/12 06:00 MHDA- 2023/04/05 06:42 CRDT- 2023/01/11 06:23 PHST- 2023/04/05 06:42 [medline] PHST- 2023/01/12 06:00 [pubmed] PHST- 2023/01/11 06:23 [entrez] AID - 10.1177/09564624221151090 [doi] PST - ppublish SO - Int J STD AIDS. 2023 Apr;34(5):355-360. doi: 10.1177/09564624221151090. Epub 2023 Jan 11.