PMID- 36630007
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230113
IS  - 1869-4101 (Print)
IS  - 1869-4101 (Electronic)
IS  - 1869-4101 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Jan 11
TI  - Impact of glycemic control on biventricular function in patients with type 2 
      diabetes mellitus: a cardiac magnetic resonance tissue tracking study.
PG  - 7
LID - 10.1186/s13244-022-01357-7 [doi]
LID - 7
AB  - BACKGROUND: Poor glycemic control is associated with left ventricular (LV) 
      dysfunction in patients with type 2 diabetes mellitus (T2DM). Nonetheless, the 
      association between glycemic control and right ventricular (RV) function in T2DM 
      has not been studied. This study aimed to evaluate the correlation between 
      glycemic control and biventricular function and assess whether one ventricular 
      function was mediated by the other ventricular changes using cardiac magnetic 
      resonance. MATERIALS AND METHODS: A total of 91 T2DM patients with normal 
      ejection fraction were enrolled and divided into two groups according to glycated 
      hemoglobin (HbA1c) with a cut off 7%. Twenty controls were included. 
      Biventricular ventricular strain parameters, including global peak systolic 
      radial strain, global peak systolic circumferential strain (GCS), global peak 
      systolic longitudinal strain (GLS), peak diastolic radial strain rate (RSR), peak 
      diastolic circumferential strain rate (CSR) and peak diastolic longitudinal 
      strain rate (LSR) were measured. RESULTS: Compared with controls, patients with 
      both HbA1c < 7% and HbA1c >/= 7% showed significantly lower LVGCS, LVGLS, LVCSR, 
      LVLSR, RVGLS, RVRSR, RVCSR and RVLSR. Patients with HbA1c >/= 7% elicited 
      significantly higher RVGCS than controls and lower LVGLS, LVCSR, LVLSR, RVGLS and 
      RVLSR. Multivariable linear regression demonstrated that HbA1c was independently 
      associated with LVGLS, LVLSR, RVGLS and RVLSR after adjustment for traditional 
      risk factors. LV (RV) was not statistically mediated by the other ventricular 
      alterations. CONCLUSION: In T2DM patients, glycemic control was independently 
      associated with impaired LV and RV systolic and diastolic function and these 
      associations were not mediated by the other ventricular changes.
CI  - (c) 2023. The Author(s).
FAU - Zhu, Jing
AU  - Zhu J
AUID- ORCID: 0000-0002-0526-9020
AD  - Department of Radiology, The First Affiliated Hospital of Chengdu Medical 
      College, Chengdu, 610041, China. zhujingcmc@163.com.
FAU - Li, Wenjia
AU  - Li W
AD  - Department of Radiology, The First Affiliated Hospital of Chengdu Medical 
      College, Chengdu, 610041, China.
FAU - Chen, Fang
AU  - Chen F
AD  - Department of Neurology, Xindu District People's Hospital of Chengdu, Chengdu, 
      610041, China.
FAU - Xie, Zhen
AU  - Xie Z
AD  - Department of Radiology, The First Affiliated Hospital of Chengdu Medical 
      College, Chengdu, 610041, China.
FAU - Zhuo, Kaimin
AU  - Zhuo K
AD  - Department of Radiology, The First Affiliated Hospital of Chengdu Medical 
      College, Chengdu, 610041, China.
FAU - Huang, Ruijue
AU  - Huang R
AD  - Department of Basic Medicine, Hainan Vocational University of Science and 
      Technology, Haikou, 570100, China. hrjhuangruijue@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230111
PL  - Germany
TA  - Insights Imaging
JT  - Insights into imaging
JID - 101532453
PMC - PMC9833026
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Glycemic control
OT  - Left ventricular strains
OT  - Right ventricular strains
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2023/01/12 06:00
MHDA- 2023/01/12 06:01
PMCR- 2023/01/11
CRDT- 2023/01/11 11:19
PHST- 2022/08/17 00:00 [received]
PHST- 2022/12/13 00:00 [accepted]
PHST- 2023/01/11 11:19 [entrez]
PHST- 2023/01/12 06:00 [pubmed]
PHST- 2023/01/12 06:01 [medline]
PHST- 2023/01/11 00:00 [pmc-release]
AID - 10.1186/s13244-022-01357-7 [pii]
AID - 1357 [pii]
AID - 10.1186/s13244-022-01357-7 [doi]
PST - epublish
SO  - Insights Imaging. 2023 Jan 11;14(1):7. doi: 10.1186/s13244-022-01357-7.