PMID- 36630180
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230224
IS  - 2369-2960 (Electronic)
IS  - 2369-2960 (Linking)
VI  - 9
DP  - 2023 Jan 11
TI  - Independent and Joint Associations of BMI and Waist Circumference With the Onset 
      of Type 2 Diabetes Mellitus in Chinese Adults: Prospective Data Linkage Study.
PG  - e39459
LID - e39459
AB  - BACKGROUND: General obesity and abdominal obesity, typically measured by BMI and 
      waist circumference (WC), respectively, are associated with an increased risk of 
      type 2 diabetes mellitus (T2DM). However, the magnitude of the association of 
      these two obesity indicators and their joint association with the onset of T2DM 
      remain controversial. OBJECTIVE: The aim of this study was to investigate the 
      associations between these two obesity indicators and T2DM among the Chinese 
      population to contribute scientific evidence for appropriate T2DM interventions. 
      METHODS: A cohort of 3001 eligible participants was selected from the Ningbo 
      Adult Chronic Disease Surveillance Project running since 2015. Based on BMI, 
      individuals were categorized into groups of underweight or normal, overweight, 
      and obesity. Based on WC, individuals were categorized in groups of normal, 
      precentral obesity, and central obesity. Follow-up was performed by linking data 
      of the baseline data set with the diabetes registry data set and the vital 
      registry data set (both from the Ningbo Municipal Integrated Noncommunicable 
      Disease Collaborative Management System), mainly using the participants' identity 
      numbers. Follow-up was completed when a participant was diagnosed with T2DM. The 
      associations were estimated with multivariate Cox proportional hazard regression. 
      RESULTS: In the cohort, 90 of 3001 participants developed T2DM (incidence 
      density: 6.483/1000 person-years) with a median 4.72 years of follow-up. After 
      controlling for age, sex, hypertension, dyslipidemia, smoking status, and family 
      history of diabetes, the multivariate adjusted hazard ratios (HRs) across 
      underweight/normal, overweight, and obesity BMI categories were 1.000, 1.653 (95% 
      CI 1.030-2.654), and 2.375 (95% CI 1.261-4.473), respectively. The multivariate 
      adjusted HRs across the normal, precentral obesity, and central obesity WC 
      categories were 1.000, 1.215 (95% CI 0.689-2.142), and 1.663 (95% CI 
      1.016-2.723), respectively. Compared with the reference group (normal WC with an 
      underweight/normal BMI), the multivariate adjusted HR for participants with both 
      central obesity according to WC and obesity according to BMI was 2.489 (95% CI 
      1.284-4.825). CONCLUSIONS: Both elevated BMI and WC at baseline increased the 
      risk of T2DM. Compared with WC, BMI as an obesity indicator was more strongly 
      associated with the onset of T2DM.
CI  - (c)Sixuan Li, Yong Wang, Yanyan Ying, Qinghai Gong, Ge Lou, Yang Liu, Shiwei Liu, 
      Hui Li. Originally published in JMIR Public Health and Surveillance 
      (https://publichealth.jmir.org), 11.01.2023.
FAU - Li, Sixuan
AU  - Li S
AUID- ORCID: 0000-0001-8657-6542
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
FAU - Wang, Yong
AU  - Wang Y
AUID- ORCID: 0000-0002-2868-1800
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
FAU - Ying, Yanyan
AU  - Ying Y
AUID- ORCID: 0000-0001-9906-1839
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
FAU - Gong, Qinghai
AU  - Gong Q
AUID- ORCID: 0000-0002-7629-7352
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
FAU - Lou, Ge
AU  - Lou G
AUID- ORCID: 0000-0001-5191-6789
AD  - Center for Disease Control and Prevention of Chaoyang District, Beijing, China.
FAU - Liu, Yang
AU  - Liu Y
AUID- ORCID: 0000-0002-1550-5533
AD  - Shanghai Pudong New Area Center for Disease Control and Prevention, Pudong 
      Institute of Preventive Medicine, Fudan University, Shanghai, China.
FAU - Liu, Shiwei
AU  - Liu S
AUID- ORCID: 0000-0002-5013-3536
AD  - Chinese Center for Disease Control and Prevention, Bejing, China.
FAU - Li, Hui
AU  - Li H
AUID- ORCID: 0000-0002-4872-6279
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20230111
PL  - Canada
TA  - JMIR Public Health Surveill
JT  - JMIR public health and surveillance
JID - 101669345
SB  - IM
MH  - Adult
MH  - Humans
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/epidemiology/complications
MH  - East Asian People
MH  - Obesity/epidemiology
MH  - Obesity, Abdominal/complications/epidemiology
MH  - Overweight/complications
MH  - Prospective Studies
MH  - Risk Factors
MH  - Thinness/complications
MH  - Waist Circumference
MH  - China
PMC - PMC9878373
OTO - NOTNLM
OT  - body mass index
OT  - data linkage
OT  - epidemiology
OT  - hazard ratio
OT  - prospective study
OT  - type 2 diabetes mellitus
OT  - waist circumference
COIS- Conflicts of Interest: None declared.
EDAT- 2023/01/12 06:00
MHDA- 2023/01/14 06:00
PMCR- 2023/01/11
CRDT- 2023/01/11 11:53
PHST- 2022/05/11 00:00 [received]
PHST- 2022/11/26 00:00 [accepted]
PHST- 2022/11/19 00:00 [revised]
PHST- 2023/01/11 11:53 [entrez]
PHST- 2023/01/12 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2023/01/11 00:00 [pmc-release]
AID - v9i1e39459 [pii]
AID - 10.2196/39459 [doi]
PST - epublish
SO  - JMIR Public Health Surveill. 2023 Jan 11;9:e39459. doi: 10.2196/39459.