PMID- 36630584
OWN - NLM
STAT- MEDLINE
DCOM- 20230208
LR  - 20230307
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 199
IP  - 2
DP  - 2023 Feb 1
TI  - The Therapeutic Application of Stem Cells and Their Derived Exosomes in the 
      Treatment of Radiation-Induced Skin Injury.
PG  - 182-201
LID - 10.1667/RADE-22-00023.1 [doi]
AB  - Radiation-induced skin injury (RISI) is a serious concern for nuclear accidents 
      and cancer radiotherapy, which seriously affects the quality of life of patients. 
      This injury differs from traditional wounds due to impaired healing and the 
      propensity to recurrence and is divided into acute and chronic phases on the 
      basis of the injury time. Unfortunately, there are few effective therapies for 
      preventing or mitigating this injury. Over the last few decades, various studies 
      have focused on the effects of stem cell-based therapies to address the tissue 
      repair and regeneration of irradiated skin. These stem cells modulate 
      inflammation and instigate tissue repair by differentiating into specific kinds 
      of cells or releasing paracrine factors. Stem cell-based therapies, including 
      bone marrow-derived stem cells (BMSCs), adipose-derived stem cells (ADSCs) and 
      stromal vascular fraction (SVF), have been reported to facilitate wound healing 
      after radiation exposure. Moreover, stem cell-derived exosomes have recently been 
      suggested as an effective and cell-free approach to support skin regeneration, 
      circumventing the concerns respecting direct application of stem cells. Based on 
      the literature on stem cell-based therapies for radiation-induced skin injury, we 
      summarize the characteristics of different stem cells and describe their latest 
      animal and clinical applications, as well as potential mechanisms. The promise of 
      stem-cell based therapies against radiation-induced skin injury contribute to our 
      response to nuclear events and smooth progress of cancer radiotherapy.
CI  - (c)2023 by Radiation Research Society. All rights of reproduction in any form 
      reserved.
FAU - Yang, Ping
AU  - Yang P
AD  - Laboratory of Radiation Medicine, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Zhang, Shuaijun
AU  - Zhang S
AD  - Laboratory of Radiation Medicine, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Yan, Tao
AU  - Yan T
AD  - Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
AD  - Second Affiliated Hospital of Chengdu Medical College, China National Nuclear 
      Corporation 416 Hospital, Chengdu 610051, China.
FAU - Li, Fengsheng
AU  - Li F
AD  - PLA Rocket Rorce Characteristic Medical Center, Beijing 100088, China.
FAU - Zhang, Shuyu
AU  - Zhang S
AD  - Laboratory of Radiation Medicine, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
AD  - Second Affiliated Hospital of Chengdu Medical College, China National Nuclear 
      Corporation 416 Hospital, Chengdu 610051, China.
AD  - NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central 
      Hospital, Mianyang 621099, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Animals
MH  - *Exosomes
MH  - Quality of Life
MH  - Adipose Tissue
MH  - Skin/injuries
MH  - Stem Cells
MH  - *Radiation Injuries/etiology/therapy
MH  - *Neoplasms
EDAT- 2023/01/12 06:00
MHDA- 2023/02/09 06:00
CRDT- 2023/01/11 14:42
PHST- 2022/01/15 00:00 [received]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2023/01/12 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2023/01/11 14:42 [entrez]
AID - 490181 [pii]
AID - 10.1667/RADE-22-00023.1 [doi]
PST - ppublish
SO  - Radiat Res. 2023 Feb 1;199(2):182-201. doi: 10.1667/RADE-22-00023.1.