PMID- 36631451
OWN - NLM
STAT- MEDLINE
DCOM- 20230210
LR  - 20230215
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan 12
TI  - Serum complement proteins rather than inflammatory factors is effective in 
      predicting psychosis in individuals at clinical high risk.
PG  - 9
LID - 10.1038/s41398-022-02305-1 [doi]
LID - 9
AB  - Immunological/inflammatory factors are implicated in the development of 
      psychosis. Complement is a key driver of inflammation; however, it remains 
      unknown which factor is better at predicting the onset of psychosis. This study 
      aimed to compare the alteration and predictive performance of inflammation and 
      complement in individuals at clinical high risk (CHR). We enrolled 49 individuals 
      at CHR and 26 healthy controls (HCs). Twenty-five patients at CHR had converted 
      to psychosis (converter) by the 3-year follow-up. Inflammatory cytokines, 
      including interleukin (IL)-1beta, 6, 8, 10, tumor necrosis factor-alpha (TNF-alpha), 
      macrophage colony-stimulating factor levels, and complement proteins (C1q, C2, 
      C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H) were measured by enzyme-linked 
      immunosorbent assay at baseline. Except for TNF- alpha, none of the inflammatory 
      cytokines reached a significant level in either the comparison of CHR individuals 
      and HC or between CHR-converters and non-converters. The C5, C3, D, I, and H 
      levels were significantly lower (C5, p = 0.006; C3, p = 0.009; D, p = 0.026; I, 
      p = 0.016; H, p = 0.019) in the CHR group than in the HC group. Compared to 
      non-converters, converters had significantly lower levels of C5 (p = 0.012) and 
      C5a (p = 0.007). None of the inflammatory factors, but many complement factors, 
      showed significant correlations with changes in general function and symptoms. 
      None of the inflammatory markers, except for C5a and C5, were significant in the 
      discrimination of conversion outcomes in CHR individuals. Our results suggest 
      that altered complement levels in the CHR population are more associated with 
      conversion to psychosis than inflammatory factors. Therefore, an activated 
      complement system may precede the first-episode of psychosis and contribute to 
      neurological pathogenesis at the CHR stage.
CI  - (c) 2023. The Author(s).
FAU - Zhang, TianHong
AU  - Zhang T
AUID- ORCID: 0000-0002-5379-7119
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China. zhang_tianhong@126.com.
FAU - Zeng, JiaHui
AU  - Zeng J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Ye, JiaYi
AU  - Ye J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Gao, YuQing
AU  - Gao Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Hu, YeGang
AU  - Hu Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Liu, HaiChun
AU  - Liu H
AD  - Department of Automation, Shanghai Jiao Tong University, Shanghai, 200240, PR 
      China.
FAU - Chen, Tao
AU  - Chen T
AD  - Department of Automation, Shanghai Jiao Tong University, Shanghai, 200240, PR 
      China.
AD  - Big Data Research Lab, University of Waterloo, Waterloo, ON, Canada.
AD  - Labor and Worklife Program, Harvard University, Cambridge, MA, USA.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China.
FAU - Wan, ChunLing
AU  - Wan C
AD  - Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders 
      (Ministry of Education), Bio-X Center, Shanghai Jiao Tong University, Shanghai, 
      PR China.
FAU - Wang, JiJun
AU  - Wang J
AUID- ORCID: 0000-0001-5427-7425
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Intelligent Psychological Evaluation and Intervention Engineering 
      Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai, 200030, PR China. jijunwang27@163.com.
AD  - Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), 
      Chinese Academy of Science, Beijing, PR China. jijunwang27@163.com.
AD  - Brain Science and Technology Research Center, Shanghai Jiao Tong University, 
      Shanghai, PR China. jijunwang27@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230112
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-36-7 (Complement System Proteins)
RN  - 80295-33-6 (Complement C1q)
RN  - 80295-43-8 (Complement C3b)
RN  - 80295-50-7 (Complement C4b)
RN  - 80295-55-2 (Complement C5b)
SB  - IM
MH  - Humans
MH  - Cytokines/blood/chemistry
MH  - Inflammation/metabolism
MH  - *Psychotic Disorders/blood/diagnosis
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha
MH  - *Complement System Proteins/chemistry
MH  - Complement C1q/chemistry
MH  - Complement C3b/chemistry
MH  - Complement C4b/chemistry
MH  - Complement C5b/chemistry
PMC - PMC9834035
COIS- The authors declare no competing interests.
EDAT- 2023/01/12 06:00
MHDA- 2023/01/14 06:00
PMCR- 2023/01/12
CRDT- 2023/01/11 23:13
PHST- 2022/09/12 00:00 [received]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2022/12/16 00:00 [revised]
PHST- 2023/01/11 23:13 [entrez]
PHST- 2023/01/12 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2023/01/12 00:00 [pmc-release]
AID - 10.1038/s41398-022-02305-1 [pii]
AID - 2305 [pii]
AID - 10.1038/s41398-022-02305-1 [doi]
PST - epublish
SO  - Transl Psychiatry. 2023 Jan 12;13(1):9. doi: 10.1038/s41398-022-02305-1.