PMID- 36632609
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230113
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - AdipoRon Promotes the Osseointegration of Dental Implants in Mice With Type 2 
      Diabetes Mellitus.
PG  - 697738
LID - 10.3389/fphys.2021.697738 [doi]
LID - 697738
AB  - AdipoRon is an oral active synthetic small molecule with biological functions 
      similar to adiponectin (APN). It is an APN receptor agonist that can improve 
      insulin resistance and glucose intolerance. However, the role of AdipoRon in bone 
      metabolism and related molecular mechanisms remains to be investigated. To 
      explore the effect of AdipoRon on bone absorption and bone integration of type 2 
      diabetes mellitus (T2DM) mice with implants, we established surgery-induced model 
      of osseointegration of dental implantation in T2DM mice of C57BL/6 db/db and 
      normal mice homologous to diabetic mice. Micro-CT was used to analyze the femurs 
      with the implant in the mice to detect the bone mass, H&E, and tartrate-resistant 
      acid phosphatase (TRAP), and Safranin O-fast green staining was performed to 
      analyze the bone formation and bone resorption. Bone integration-related markers 
      as Rankl, bone morphogenetic protein 2 (BMP2), osteoprotegerin (OPG), osteopontin 
      (OPN), and runt-related transcription factor 2 (Runx2) were also measured using 
      immunohistochemistry. Our results indicated that diabetic mice showed a lower 
      bone mass and decreased the osteoblast differentiation. AdipoRon attenuated 
      diabetes-impaired bone volume (BV)/total volume (TV), trabecular thickness 
      (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and bone 
      integration-related markers variation and promoted bone hyperplasia as well as 
      repressed the osteoclast formation, especially in diabetic mice. AdipoRon may 
      improve the osseointegration of dental implants in mice with T2DM by promoting 
      osteogenesis and inhibiting bone resorption, and AdipoRon may serve as a 
      promising oral strategy to improve the osseointegration ability of patients with 
      diabetes.
CI  - Copyright (c) 2021 Huang, Bi, Sun, Li, Wu and Yu.
FAU - Huang, BoRui
AU  - Huang B
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Bi, Wei
AU  - Bi W
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Sun, Yang
AU  - Sun Y
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Li, Ruixue
AU  - Li R
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Wu, Xingwen
AU  - Wu X
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Yu, Youcheng
AU  - Yu Y
AD  - Department of Dentistry, Zhongshan Hospital, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210909
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC9829077
OTO - NOTNLM
OT  - AdipoRon
OT  - dental implants
OT  - micro-CT
OT  - osseointegration
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/09/09 00:00
MHDA- 2021/09/09 00:01
PMCR- 2021/09/09
CRDT- 2023/01/12 02:03
PHST- 2021/04/20 00:00 [received]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2023/01/12 02:03 [entrez]
PHST- 2021/09/09 00:00 [pubmed]
PHST- 2021/09/09 00:01 [medline]
PHST- 2021/09/09 00:00 [pmc-release]
AID - 10.3389/fphys.2021.697738 [doi]
PST - epublish
SO  - Front Physiol. 2021 Sep 9;12:697738. doi: 10.3389/fphys.2021.697738. eCollection 
      2021.