PMID- 36632939
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230519
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 36
IP  - 5
DP  - 2023 May
TI  - Assessment of Early Diastolic Intraventricular Pressure Difference in Children by 
      Blood Speckle-Tracking Echocardiography.
PG  - 523-532.e3
LID - S0894-7317(23)00007-X [pii]
LID - 10.1016/j.echo.2022.12.025 [doi]
AB  - BACKGROUND: The lack of reliable echocardiographic techniques to assess diastolic 
      function in children is a major clinical limitation. Our aim was to develop and 
      validate the intraventricular pressure difference (IVPD) calculation using blood 
      speckle-tracking (BST) and investigate the method's potential role in the 
      assessment of diastolic function in children. METHODS: Blood speckle-tracking 
      allows two-dimensional angle-independent blood flow velocity estimation. Blood 
      speckle-tracking images of left ventricular (LV) inflow from the apical 4-chamber 
      view in 138 controls, 10 patients with dilated cardiomyopathies (DCMs), and 21 
      patients with hypertrophic cardiomyopathies (HCMs) <18 years of age were analyzed 
      to study LV IVPD during early diastole. Reproducibility of the IVPD analysis was 
      assessed, IVPD estimates from BST and color M mode were compared, and the 
      validity of the BST-based IVPD calculations was tested in a computer flow model. 
      RESULTS: Mean IVPD was significantly higher in controls (-2.28 +/- 0.62 mm Hg) 
      compared with in DCM (-1.21 +/- 0.39 mm Hg, P < .001) and HCM (-1.57 +/- 0.47 mm Hg, 
      P < .001) patients. Feasibility was 88.3% in controls, 80% in DCM patients, and 
      90.4% in HCM patients. The peak relative negative pressure occurred earlier at 
      the apex than at the base and preceded the peak E-wave LV filling velocity, 
      indicating that it represents diastolic suction. Intraclass correlation 
      coefficients for intra- and interobserver variability were 0.908 and 0.702, 
      respectively. There was a nonsignificant mean difference of 0.15 mm Hg between 
      IVPD from BST and color M mode. Estimation from two-dimensional velocities 
      revealed a difference in peak IVPD of 0.12 mm Hg (6.6%) when simulated in a 
      three-dimensional fluid mechanics model. CONCLUSIONS: Intraventricular pressure 
      difference calculation from BST is highly feasible and provides information on 
      diastolic suction and early filling in children with heart disease. 
      Intraventricular pressure difference was significantly reduced in children with 
      DCM and HCM compared with controls, indicating reduced early diastolic suction in 
      these patient groups.
CI  - Copyright (c) 2023 American Society of Echocardiography. All rights reserved.
FAU - Sorensen, Kristian
AU  - Sorensen K
AD  - Department of Circulation and Medical Imaging, Norwegian University of Science 
      and Technology, Trondheim, Norway; Division of Alesund Hospital, Department of 
      Pediatrics, More and Romsdal Hospital Trust, Alesund, Norway. Electronic address: 
      kristian.sorensen@ntnu.no.
FAU - Fadnes, Solveig
AU  - Fadnes S
AD  - Department of Circulation and Medical Imaging, Norwegian University of Science 
      and Technology, Trondheim, Norway; Division of Alesund Hospital, Department of 
      Pediatrics, More and Romsdal Hospital Trust, Alesund, Norway.
FAU - Mertens, Luc
AU  - Mertens L
AD  - Department of Cardiology, the Hospital for Sick Children, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Henry, Matthew
AU  - Henry M
AD  - Department of Cardiology, the Hospital for Sick Children, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Segers, Patrick
AU  - Segers P
AD  - Department of Electronics and Information Systems, IBiTech-bioMMeda, Ghent 
      University, Ghent, Belgium.
FAU - Lovstakken, Lasse
AU  - Lovstakken L
AD  - Department of Circulation and Medical Imaging, Norwegian University of Science 
      and Technology, Trondheim, Norway.
FAU - Nyrnes, Siri Ann
AU  - Nyrnes SA
AD  - Department of Circulation and Medical Imaging, Norwegian University of Science 
      and Technology, Trondheim, Norway; Children's Clinic, St. Olav;s Hospital, 
      Trondheim University Hospital, Trondheim, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230109
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Humans
MH  - Child
MH  - Ventricular Pressure/physiology
MH  - Stroke Volume/physiology
MH  - Reproducibility of Results
MH  - Echocardiography/methods
MH  - Heart Ventricles/diagnostic imaging
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging
MH  - *Cardiomyopathy, Dilated
MH  - Diastole/physiology
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - Blood speckle-tracking
OT  - Diastolic function
OT  - High frame rate ultrasound imaging
OT  - Intraventricular pressure difference
OT  - Intraventricular pressure gradients
EDAT- 2023/01/13 06:00
MHDA- 2023/05/08 06:41
CRDT- 2023/01/12 04:38
PHST- 2022/11/18 00:00 [received]
PHST- 2022/12/24 00:00 [revised]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/05/08 06:41 [medline]
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/01/12 04:38 [entrez]
AID - S0894-7317(23)00007-X [pii]
AID - 10.1016/j.echo.2022.12.025 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2023 May;36(5):523-532.e3. doi: 
      10.1016/j.echo.2022.12.025. Epub 2023 Jan 9.