PMID- 36633023
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20230216
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 166
DP  - 2022 Dec 22
TI  - [Self-reported maternal adverse events of covid-19 vaccination during pregnancy].
LID - D6831 [pii]
AB  - OBJECTIVE: To describe the self-reported maternal adverse events (AEs) of 
      covid-19 vaccination during pregnancy. DESIGN: The Dutch Pregnancy Drug Register 
      ("Moeders van Morgen"), is a prospective cohort study among pregnant women in the 
      Netherlands. METHOD: Using online questionnaires, women reported whether they 
      received a covid-19 vaccination and the self-perceived AEs after vaccination. We 
      included women who received their first covid-19 vaccination during pregnancy. We 
      assessed the maternal AEs by vaccine dose, type of vaccine (BioNTech/Pfizer, 
      Moderna, AstraZeneca, and Janssen) and moment of vaccination in pregnancy. 
      RESULTS: 4348 women received their first covid-19 vaccination during pregnancy 
      and were included. Of these, 2787 women also reported a second dose during 
      pregnancy. After the first dose, AEs were less often reported for BioNTech/Pfizer 
      (56% >/=1 AE), compared to Moderna (68% >/=1 AE) or AstraZeneca (87% >/=1 AE). After 
      the second dose, AEs were less often reported for BioNTech/Pfizer (44% >/=1 AE) 
      compared to Moderna (76% >/=1 AE). Injection site reactions, myalgia and fatigue 
      were reported most frequently. There was large variation in the percentage 
      reporting pyrexia/fever between the different vaccines (3%, 22%, and 10% after 
      the second dose of BioNTech/Pfizer, Moderna, and Astrazeneca respectively). There 
      were no major differences in the rates of AEs between vaccination in the first, 
      second, or third trimester. CONCLUSION: The adverse event pro fi le among women who 
      were vaccinated against covid-19 during pregnancy do not indicate any safety 
      concerns. Considering the reported maternal AEs, the BioNTech/Pfizer vaccine 
      seems best for vaccination during pregnancy.
FAU - Woestenberg, Petra J
AU  - Woestenberg PJ
AD  - Bijwerkingencentrum Lareb, Den Bosch.
AD  - Contact: Petra J. Woestenberg (p.woestenberg@lareb.nl).
FAU - Litjens, Carlijn H C
AU  - Litjens CHC
AD  - Bijwerkingencentrum Lareb, Den Bosch.
FAU - Vissers, Lieke C M
AU  - Vissers LCM
AD  - Bijwerkingencentrum Lareb, Den Bosch.
FAU - Kant, Agnes
AU  - Kant A
AD  - Bijwerkingencentrum Lareb, Den Bosch.
FAU - Berrens, Marianne
AU  - Berrens M
AD  - Bijwerkingencentrum Lareb, Den Bosch.
FAU - Vorstenbosch, Saskia
AU  - Vorstenbosch S
AD  - Bijwerkingencentrum Lareb, Den Bosch.
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Maternale bijwerkingen na covid-19-vaccinatie in de zwangerschap.
DEP - 20221222
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Self Report
MH  - *COVID-19 Vaccines/adverse effects
MH  - Prospective Studies
MH  - *COVID-19/epidemiology/prevention & control
MH  - Vaccination/adverse effects
MH  - Fever
EDAT- 2023/01/13 06:00
MHDA- 2023/01/14 06:00
CRDT- 2023/01/12 05:22
PHST- 2023/01/12 05:22 [entrez]
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
AID - D6831 [pii]
PST - epublish
SO  - Ned Tijdschr Geneeskd. 2022 Dec 22;166:D6831.