PMID- 36633059
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230207
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 71
IP  - 4
DP  - 2023 Feb 1
TI  - Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in Mice by Regulating 
      AHR/NRF2/NLRP3 Inflammasome Pathways through Indole-3-lactic Acid Production.
PG  - 1970-1981
LID - 10.1021/acs.jafc.2c06894 [doi]
AB  - In this study, the effectors and mechanisms of Bifidobacterium bifidum FL-276.1 
      and B. bifidum FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced 
      colitis were investigated. Both FL-276.1 and FL-228.1 significantly alleviated 
      DSS-induced colitis, whether they were supplemented from the beginning of the 
      experiment (whole course intervention) or after the DSS induction started 
      (partial intervention). Aryl hydrocarbon receptor (AHR) and the nuclear factor 
      erythroid 2-related factor 2 (NRF2) pathways were activated in mice colons, while 
      the NLR family pyrin domain containing 3 (NLRP3) was downregulated under the 
      whole course intervention modes. Indole-3-lactic acid, an AHR ligand produced by 
      FL-276.1 and FL-228.1, could regulate the AHR/NRF2/NLRP3 pathway in Caco-2 
      monolayers, thus upregulating the tight junction proteins and protecting the 
      integrity of the epithelial barrier. These results are conducive to promoting 
      clinical trials and product development of probiotics for alleviating colitis.
FAU - Cui, Qingyu
AU  - Cui Q
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Tian, Xiaoying
AU  - Tian X
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Liang, Xi
AU  - Liang X
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Lu, Youyou
AU  - Lu Y
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Shi, Yixin
AU  - Shi Y
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Kuerman, Malina
AU  - Kuerman M
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Wang, Rui
AU  - Wang R
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Yu Zhou
AU  - Yu Zhou
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Gong, Pimin
AU  - Gong P
AUID- ORCID: 0000-0001-8581-2806
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Lin, Kai
AU  - Lin K
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Yi, Huaxi
AU  - Yi H
AUID- ORCID: 0000-0002-8968-4263
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Li, Jiadong
AU  - Li J
AD  - R&D Center, China Innovation Probiotics Science Biotech (Shanghai) Co., Ltd., 
      Shanghai 200000, China.
FAU - Liu, Tongjie
AU  - Liu T
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
FAU - Zhang, Lanwei
AU  - Zhang L
AUID- ORCID: 0000-0003-3459-2975
AD  - College of Food Science and Engineering, Ocean University of China, Qingdao 
      266100, China.
LA  - eng
PT  - Journal Article
DEP - 20230112
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 9042-14-2 (Dextran Sulfate)
RN  - 5SW11R7M7M (indole-3-lactic acid)
RN  - 0 (Inflammasomes)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Receptors, Aryl Hydrocarbon)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - *Bifidobacterium bifidum
MH  - Caco-2 Cells
MH  - *Colitis/chemically induced/drug therapy/metabolism
MH  - Dextran Sulfate
MH  - Disease Models, Animal
MH  - Inflammasomes/metabolism
MH  - Mice, Inbred C57BL
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/genetics/metabolism
MH  - Receptors, Aryl Hydrocarbon/genetics/metabolism
OTO - NOTNLM
OT  - Bifidobacterium bifidum
OT  - aryl hydrocarbon receptor
OT  - indole-3-lactic acid
OT  - probiotics
OT  - ulcerative colitis
EDAT- 2023/01/13 06:00
MHDA- 2023/02/03 06:00
CRDT- 2023/01/12 05:24
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2023/01/12 05:24 [entrez]
AID - 10.1021/acs.jafc.2c06894 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2023 Feb 1;71(4):1970-1981. doi: 10.1021/acs.jafc.2c06894. 
      Epub 2023 Jan 12.