PMID- 36633492
OWN - NLM
STAT- MEDLINE
DCOM- 20230116
LR  - 20230118
IS  - 1465-3664 (Electronic)
IS  - 0142-6338 (Linking)
VI  - 69
IP  - 1
DP  - 2022 Dec 5
TI  - Cluster-randomized controlled trial of intermittent preventive treatment in 
      infancy using sulfadoxine-pyrimethamine (SP-IPTi): a pilot study in Nigeria.
LID - fmad001 [pii]
LID - 10.1093/tropej/fmad001 [doi]
AB  - BACKGROUND: Malaria kills a child in sub-Saharan Africa every 2 min despite 
      widely available interventions including intermittent preventive treatment in 
      infants (IPTi). Since 2010, when World Health Organization (WHO) recommended 
      IPTi, no country has implemented it. To our knowledge, no IPTi study has been 
      conducted in Nigeria. Considering severity of malaria in infancy and urgency to 
      improve malaria prevention, we proposed a study to investigate the efficacy of 
      this intervention in reducing malarial morbidity and mortality. OBJECTIVE(S): The 
      aim of this was to determine the safety and efficacy of SP-IPTi in reducing the 
      prevalence of asymptomatic malaria parasitemia and malarial-associated hospital 
      admissions. METHODS: We performed a cluster-randomized controlled trial in 1379 
      infants. SP was administered alongside routine vaccinations in immunization 
      centers randomized to intervention groups. Infants in control groups received 
      only routine vaccines. Malarial 'morbidity and adverse events were monitored 
      through passive case-detection and cross-sectional surveys'. RESULTS: SP-IPTi was 
      safe. There was no statistically significant difference in terms of risks of 
      asymptomatic parasitemia at 9 months, fever or hospitalization between our 
      control and intervention groups. CONCLUSIONS: Our study demonstrated that SP-IPTi 
      had no benefit but was well tolerated. WHO and some researchers have also 
      reported declining efficacy of SP, due to increasing drug resistance.
CI  - (c) The Author(s) [2023]. Published by Oxford University Press.
FAU - Adeleke, Olumide Thomas
AU  - Adeleke OT
AUID- ORCID: 0000-0001-6503-6416
AD  - Department of Pediatrics, Bowen University Teaching Hospital, Ogbomoso 232101, 
      Nigeria.
FAU - Oyenuga, Abayomi
AU  - Oyenuga A
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, MN 55414, USA.
FAU - Slusher, Tina M
AU  - Slusher TM
AUID- ORCID: 0000-0002-5798-5774
AD  - Department of Pediatrics, Bowen University Teaching Hospital, Ogbomoso 232101, 
      Nigeria.
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, MN 55414, USA.
AD  - Department of Pediatrics, Hennepin Healthcare, Minneapolis, MN 55404, USA.
FAU - Gbadero, Daniel A
AU  - Gbadero DA
AD  - Department of Pediatrics, Bowen University Teaching Hospital, Ogbomoso 232101, 
      Nigeria.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Trop Pediatr
JT  - Journal of tropical pediatrics
JID - 8010948
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 0 (Antimalarials)
RN  - 0 (Drug Combinations)
SB  - IM
MH  - Child
MH  - Infant
MH  - Humans
MH  - *Antimalarials/therapeutic use
MH  - Pilot Projects
MH  - Nigeria/epidemiology
MH  - Cross-Sectional Studies
MH  - Parasitemia/diagnosis/drug therapy/epidemiology
MH  - *Malaria/epidemiology/prevention & control/drug therapy
MH  - Drug Combinations
OTO - NOTNLM
OT  - Infant malaria
OT  - Intermittent preventive treatment
OT  - Malaria
OT  - Malaria prevention
OT  - Perennial malaria chemoprevention
OT  - SP-IP Ti
EDAT- 2023/01/13 06:00
MHDA- 2023/01/17 06:00
CRDT- 2023/01/12 09:44
PHST- 2023/01/12 09:44 [entrez]
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/01/17 06:00 [medline]
AID - 6986163 [pii]
AID - 10.1093/tropej/fmad001 [doi]
PST - ppublish
SO  - J Trop Pediatr. 2022 Dec 5;69(1):fmad001. doi: 10.1093/tropej/fmad001.