PMID- 36634666
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230610
IS  - 2713-4148 (Electronic)
IS  - 2713-4148 (Linking)
VI  - 66
IP  - 6
DP  - 2023 Jun
TI  - Recent topics on gastrointestinal allergic disorders.
PG  - 240-249
LID - 10.3345/cep.2022.01053 [doi]
AB  - Gastrointestinal (GI) allergies are broadly associated with food allergies and 
      divided into groups based on the degree of allergen-specific immunoglobulin E 
      (IgE) involvement: IgE-mediated, non-IgE-mediated, and mixed. Non-IgE-mediated GI 
      food allergies are mostly observed in neonates and infants and include food 
      protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic 
      proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). In addition to 
      the classical phenotype, unique phenotypes such as vomiting and bloody stool, 
      suspected sepsis, and overlapping eosinophilic GI disorders (EGIDs) have 
      increased in Japan over the past 2 decades. Some of these cases were defined as 
      having chronic FPIES. More recently, cases of hen's-egg FPIES in Japan have 
      increased dramatically since 2018, albeit for unknown reasons. Typical mixed-type 
      food allergies are EGIDs, characterized by prominent eosinophil infiltration in 
      the GI tract leading to GI symptoms. EGIDs are broadly classified into 
      eosinophilic esophagitis (EoE) and non-EoE EGIDs that involve the GI tract with 
      the exception of the esophagus. Of the EGIDs, EoE is the best known, as the 
      number of cases has increased dramatically in Western countries, whereas 
      pediatric EoE remains rare in Asia and non-EoE EGIDs may be more prevalent in 
      Japan. A recent Japanese national survey showed that pediatric non-EoE EGIDs were 
      persistent and severe compared to those in adults, possibly requiring further 
      effective therapeutic options. Among the EGIDs, FPIAP is pathologically diagnosed 
      as an infantile form of eosinophilic colitis. In addition, recent FPIES and FPE 
      cases also involved eosinophilic inflammation. Recent cases of GI allergies may 
      be associated with type 2 inflammation. A better understanding of the 
      interactions between GI allergies and type 2 inflammation may clarify the 
      pathogenesis of the recent increase in GI allergies.
FAU - Yamada, Yoshiyuki
AU  - Yamada Y
AD  - Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, 
      Japan.
AD  - Division of Allergy and Immunology, Gunma Children's Medical Center, Shibukawa, 
      Gunma, Japan.
LA  - eng
GR  - H29-Nanchi-ippan-042/Ministry of Health, Labour and Welfare/
GR  - 20FC1016/Ministry of Health, Labour and Welfare/
GR  - 16K11358/Ministry of Education, Culture, Sports, Science, and Technology/
GR  - 21K07833/Ministry of Education, Culture, Sports, Science, and Technology/
PT  - Journal Article
DEP - 20230109
PL  - Korea (South)
TA  - Clin Exp Pediatr
JT  - Clinical and experimental pediatrics
JID - 101761234
PMC - PMC10248316
OTO - NOTNLM
OT  - Eosinophilic enteropathy
OT  - Eosinophilic esophagitis
OT  - Food hypersensitivity
COIS- Conflicts of interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/01/13 06:00
MHDA- 2023/01/13 06:01
PMCR- 2023/01/09
CRDT- 2023/01/12 18:30
PHST- 2022/08/20 00:00 [received]
PHST- 2022/12/24 00:00 [accepted]
PHST- 2023/01/13 06:01 [medline]
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/01/12 18:30 [entrez]
PHST- 2023/01/09 00:00 [pmc-release]
AID - cep.2022.01053 [pii]
AID - cep-2022-01053 [pii]
AID - 10.3345/cep.2022.01053 [doi]
PST - ppublish
SO  - Clin Exp Pediatr. 2023 Jun;66(6):240-249. doi: 10.3345/cep.2022.01053. Epub 2023 
      Jan 9.