PMID- 36635730
OWN - NLM
STAT- MEDLINE
DCOM- 20230116
LR  - 20230202
IS  - 1756-6606 (Electronic)
IS  - 1756-6606 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Jan 12
TI  - Circadian rhythms in the blood-brain barrier: impact on neurological disorders 
      and stress responses.
PG  - 5
LID - 10.1186/s13041-023-00997-0 [doi]
LID - 5
AB  - Circadian disruption has become more prevalent in society due to the increase in 
      shift work, sleep disruption, blue light exposure, and travel via different time 
      zones. The circadian rhythm is a timed transcription-translation feedback loop 
      with positive regulators, BMAL1 and CLOCK, that interact with negative 
      regulators, CRY and PER, to regulate both the central and peripheral clocks. This 
      review highlights the functions of the circadian rhythm, specifically in the 
      blood-brain barrier (BBB), during both healthy and pathological states. The BBB 
      is a highly selective dynamic interface composed of CNS endothelial cells, 
      astrocytes, pericytes, neurons, and microglia that form the neurovascular unit 
      (NVU). Circadian rhythms modulate BBB integrity through regulating oscillations 
      of tight junction proteins, assisting in functions of the NVU, and modulating 
      transporter functions. Circadian disruptions within the BBB have been observed in 
      stress responses and several neurological disorders, including brain metastasis, 
      epilepsy, Alzheimer's disease, and Parkinson's disease. Further understanding of 
      these interactions may facilitate the development of improved treatment options 
      and preventative measures.
CI  - (c) 2023. The Author(s).
FAU - Schurhoff, Nicolette
AU  - Schurhoff N
AUID- ORCID: 0000-0002-5525-2948
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Suite 528, 1011 NW 15th Street, Miami, FL, 33155, USA.
FAU - Toborek, Michal
AU  - Toborek M
AUID- ORCID: 0000-0003-4475-2119
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Suite 528, 1011 NW 15th Street, Miami, FL, 33155, USA. 
      mtoborek@med.miami.edu.
AD  - Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, 40-065, Katowice, Poland. mtoborek@med.miami.edu.
LA  - eng
GR  - MH128022/MH/NIMH NIH HHS/United States
GR  - MH122235/MH/NIMH NIH HHS/United States
GR  - MH072567/MH/NIMH NIH HHS/United States
GR  - HL126559/HL/NHLBI NIH HHS/United States
GR  - DA044579/DA/NIDA NIH HHS/United States
GR  - DA039576/DA/NIDA NIH HHS/United States
GR  - DA040537/DA/NIDA NIH HHS/United States
GR  - DA050528/DA/NIDA NIH HHS/United States
GR  - DA047157/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230112
PL  - England
TA  - Mol Brain
JT  - Molecular brain
JID - 101468876
SB  - IM
MH  - Humans
MH  - *Blood-Brain Barrier/pathology
MH  - Endothelial Cells
MH  - Circadian Rhythm/physiology
MH  - Astrocytes/physiology
MH  - *Alzheimer Disease/pathology
PMC - PMC9835375
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Brain
OT  - Circadian rhythm
OT  - Neurological disorders
OT  - Stress responses
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/13 06:00
MHDA- 2023/01/17 06:00
PMCR- 2023/01/12
CRDT- 2023/01/12 23:38
PHST- 2022/08/15 00:00 [received]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/01/12 23:38 [entrez]
PHST- 2023/01/13 06:00 [pubmed]
PHST- 2023/01/17 06:00 [medline]
PHST- 2023/01/12 00:00 [pmc-release]
AID - 10.1186/s13041-023-00997-0 [pii]
AID - 997 [pii]
AID - 10.1186/s13041-023-00997-0 [doi]
PST - epublish
SO  - Mol Brain. 2023 Jan 12;16(1):5. doi: 10.1186/s13041-023-00997-0.