PMID- 36637040
OWN - NLM
STAT- MEDLINE
DCOM- 20230607
LR  - 20230607
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 37
IP  - 6
DP  - 2023 Jun
TI  - Perilla seed oil improves bone health by inhibiting bone resorption in healthy 
      Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
PG  - 2230-2241
LID - 10.1002/ptr.7728 [doi]
AB  - Accumulating evidence suggests the beneficial effect of omega-3 polyunsaturated 
      fatty acids (PUFAs) on bone mineral density (BMD). However, the effects of 
      perilla (Perilla frutescens) seed oil (PO), a rich source of alpha-linoleic acid 
      (LNA), on human bone have not yet been elucidated. This randomized, double-blind, 
      placebo-controlled trial investigated the effects of long-term PO intake on bone 
      health in Japanese adults. After screening for eligibility, 52 participants (mean 
      age 54.2 +/- 6.4 years) were randomly assigned to placebo (n = 25) and PO (n = 27) 
      groups, which received 7.0 ml of olive oil and PO daily, respectively. At 
      baseline and 12-month, quantitative ultrasound of the right calcaneus was 
      measured with an ultrasound bone densitometer and percentage of the Young Adult 
      Mean (%YAM) was calculated. Serum levels of tartrate-resistant acid phosphatase 
      5b (TRACP-5b), and bone alkaline phosphatase (BALP) were evaluated. In addition, 
      PUFA levels in the erythrocyte plasma membrane (RBC-PM), serum biological 
      antioxidant potential (BAP), and diacron reactive oxygen metabolites (d-ROM) were 
      evaluated. Compared with the placebo group, %YAM levels increased and serum 
      TRACP-5b levels decreased significantly in the PO group at 12-month, while serum 
      BALP levels remained unchanged. Moreover, RBC-PM LNA levels and BAP/d-ROM ratios 
      increased significantly in the PO compared with the placebo group. These results 
      suggest that long-term PO intake may improve age-related BMD decline by 
      suppressing bone resorption and increasing LNA levels.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Matsuzaki, Kentaro
AU  - Matsuzaki K
AUID- ORCID: 0000-0002-5942-8840
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
FAU - Hossain, Shahdat
AU  - Hossain S
AUID- ORCID: 0000-0003-2970-2324
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
AD  - Department of Biochemistry and Molecular Biology, Jahangirnagar University, 
      Savar, Bangladesh.
FAU - Wakatsuki, Harumi
AU  - Wakatsuki H
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
FAU - Tanabe, Yoko
AU  - Tanabe Y
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
FAU - Ohno, Miho
AU  - Ohno M
AD  - Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Japan.
FAU - Kato, Setsushi
AU  - Kato S
AD  - Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Japan.
FAU - Shido, Osamu
AU  - Shido O
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
FAU - Hashimoto, Michio
AU  - Hashimoto M
AUID- ORCID: 0000-0002-3726-4347
AD  - Department of Environmental Physiology, Faculty of Medicine, Shimane University, 
      Izumo, Shimane, Japan.
LA  - eng
GR  - 23500955/Japan Society for the Promotion of Science/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230113
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 68132-21-8 (perilla seed oil)
RN  - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
RN  - 0 (Plant Oils)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Tartrate-Resistant Acid Phosphatase
MH  - *Bone Density
MH  - East Asian People
MH  - Plant Oils/pharmacology/therapeutic use
MH  - *Bone Resorption/drug therapy
MH  - Biomarkers
OTO - NOTNLM
OT  - Perilla seed oil
OT  - bone mineral density
OT  - bone resorption
OT  - alpha-linolenic acid
EDAT- 2023/01/14 06:00
MHDA- 2023/06/07 06:42
CRDT- 2023/01/13 06:32
PHST- 2022/12/19 00:00 [revised]
PHST- 2022/04/24 00:00 [received]
PHST- 2022/12/29 00:00 [accepted]
PHST- 2023/06/07 06:42 [medline]
PHST- 2023/01/14 06:00 [pubmed]
PHST- 2023/01/13 06:32 [entrez]
AID - 10.1002/ptr.7728 [doi]
PST - ppublish
SO  - Phytother Res. 2023 Jun;37(6):2230-2241. doi: 10.1002/ptr.7728. Epub 2023 Jan 13.