PMID- 36637634
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230320
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 42
IP  - 4
DP  - 2023 Apr
TI  - Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 
      prior to vaccinations and new variants: a historical perspective.
PG  - 1171-1175
LID - 10.1007/s10067-023-06507-w [doi]
AB  - We described the profile and outcome of Filipino patients with inflammatory 
      rheumatic diseases (IRDs) who developed COVID-19 (IRD-C19) during the onset of 
      the pandemic, prior to vaccinations and variants. We obtained de-identified data 
      of Filipino patients with IRD-C19 from the Global Rheumatology Alliance registry 
      from March 2020 to August 2021. Descriptive statistics and multivariate analyses 
      were applied. Registered were 164 patients (mean age 44 years; 70% female). The 
      most common IRDs were systemic lupus erythematosus (SLE, 41.4%), rheumatoid 
      arthritis (RA, 15.2%), and gout (14.6%). Majority were receiving conventional 
      DMARDs (59.1%) and/or glucocorticoid therapy (GC, 51.2%). Half (58.5%) were 
      hospitalized, with risk higher in active IRD (OR 3.7), heart disease (8.52), and 
      hypertension (8.73); and lower in SLE patients (0.15). Among hospitalized 
      patients, 76% needed supplemental oxygen. Heart disease (6.28), hypertension 
      (7.6), and moderate-to-high IRD activity (3.37) were associated with higher odds 
      of requiring oxygen supplementation. Hypertension was associated with mechanical 
      ventilation (8.23). Twenty-four (15%) patients died, with odds lower if on 
      prednisone >/= 10 mg/day (0.17) and with other autoimmune IRDs aside from SLE and 
      RA (0.05). Among patients with IRD-C19 prior to vaccinations and variants, higher 
      disease activity, hypertension, and heart disease were associated with poorer 
      outcomes. Prednisone >/= 10 mg/day was associated with lower odds of death. This 
      study provides valuable historical information, emphasizing the need for 
      continued data collection to clarify COVID-19's impact.
CI  - (c) 2023. The Author(s), under exclusive licence to International League of 
      Associations for Rheumatology (ILAR).
FAU - Zamora-Abrahan, Geraldine Tong
AU  - Zamora-Abrahan GT
AUID- ORCID: 0000-0003-3125-9114
AD  - University of the Philippines Manila, Manila, Philippines. gtzamora@up.edu.ph.
FAU - Salido, Evelyn Osio
AU  - Salido EO
AUID- ORCID: 0000-0003-1653-2143
AD  - University of the Philippines Manila, Manila, Philippines.
AD  - Asian Hospital and Medical Center, Manila, Philippines.
FAU - Lichauco, Juan Javier Tayengco
AU  - Lichauco JJT
AD  - St. Luke's Medical Center, Manila, Philippines.
FAU - Gutierrez-Rubio, Anna Kristina Manahan
AU  - Gutierrez-Rubio AKM
AUID- ORCID: 0000-0003-1322-9827
AD  - Makati Medical Center, Manila, Philippines.
FAU - Rivera-Go, Ivy Catherine Talavera
AU  - Rivera-Go ICT
AD  - Medical Center Manila, Manila, Philippines.
FAU - Cortez, Karen Joy Castaneda
AU  - Cortez KJC
AD  - Baguio General Hospital and Medical Center, Baguio City, Philippines.
FAU - Suilan, Katrina Elys Arada
AU  - Suilan KEA
AD  - University of the Philippines Manila, Manila, Philippines.
FAU - Villo, Jimmy Gene Bobot
AU  - Villo JGB
AD  - East Avenue Medical Center, Manila, Philippines.
FAU - Del Rosario, Adora Gatlabayan
AU  - Del Rosario AG
AD  - East Avenue Medical Center, Manila, Philippines.
LA  - eng
PT  - Journal Article
DEP - 20230113
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adult
MH  - Male
MH  - *COVID-19/complications
MH  - Prednisone
MH  - *Arthritis, Rheumatoid/complications
MH  - *Rheumatic Fever
MH  - *Lupus Erythematosus, Systemic/drug therapy/complications
MH  - *Hypertension/complications
MH  - *Heart Diseases
MH  - Vaccination
MH  - *Rheumatic Diseases/drug therapy/complications
PMC - PMC9838254
OTO - NOTNLM
OT  - COVID-19
OT  - COVID-19 immunopathology
OT  - Filipino patients
OT  - Global Rheumatology Alliance
OT  - Registry
OT  - Rheumatic disease
EDAT- 2023/01/14 06:00
MHDA- 2023/03/21 06:00
PMCR- 2023/01/13
CRDT- 2023/01/13 11:20
PHST- 2022/01/28 00:00 [received]
PHST- 2023/01/04 00:00 [accepted]
PHST- 2023/01/03 00:00 [revised]
PHST- 2023/01/14 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/01/13 11:20 [entrez]
PHST- 2023/01/13 00:00 [pmc-release]
AID - 10.1007/s10067-023-06507-w [pii]
AID - 6507 [pii]
AID - 10.1007/s10067-023-06507-w [doi]
PST - ppublish
SO  - Clin Rheumatol. 2023 Apr;42(4):1171-1175. doi: 10.1007/s10067-023-06507-w. Epub 
      2023 Jan 13.