PMID- 36638549
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230218
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 107
DP  - 2023 Feb
TI  - Life events and the onset of motor symptoms in Parkinson's disease.
PG  - 105283
LID - S1353-8020(23)00006-8 [pii]
LID - 10.1016/j.parkreldis.2023.105283 [doi]
AB  - BACKGROUND: Whether there may be any relationship between stressful or traumatic 
      life events (LE) and the subsequent motor symptoms onset in Parkinson's disease 
      (PD) is still controversial. OBJECTIVES: To explore whether a subjectively 
      perceived as stressful or traumatic LE were more frequently present in a group of 
      recent motor onset parkinsonian patients (Recent Onset Parkinsonism - ROP) 
      compared with healthy controls (HC) and a group of patients already diagnosed as 
      PD. METHODS: A consecutive series of 139 ROP patients, 138 matched PD patients 
      and 138 HC were pooled through a validated LE exposure questionnaire evaluating 
      the number of patients affected by LE and the amount of LE per group occurred in 
      the last year, segregating by subjective severity in total and severe LE. 
      RESULTS: There was no significant difference in the percentage of patients 
      affected by total (p = 0.134) nor by severe (p = 0.133) LE within the 3 groups. 
      No significant difference was observed in the number of total LE between ROP and 
      HC (p = 0.063), ROP and PD (p = 0.688), nor in severe LE (ROP vs. HC, p = 0.637. 
      ROP vs. PD, p = 0.500). CONCLUSIONS: During the year of parkinsonian motor 
      symptoms onset, the number of ROP patients exposed to total or severe LE or the 
      amount of total or severe LE suffered by ROP were not significantly different to 
      the group of PD patients or HC. A casual relationship between LE and the onset of 
      motor symptoms in parkinsonian patients may be suggested.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Paez-Maggio, M
AU  - Paez-Maggio M
AD  - Movement Disorders Service, Neuroscience Department, Institute for Neurological 
      Research Raul Carrea (FLENI), Buenos Aires, Argentina.
FAU - Rossi, M
AU  - Rossi M
AD  - Movement Disorders Service, Neuroscience Department, Institute for Neurological 
      Research Raul Carrea (FLENI), Buenos Aires, Argentina; National Research Council 
      (CONICET), Buenos Aires, Argentina.
FAU - Martinez, V
AU  - Martinez V
AD  - Movement Disorders Service, Neuroscience Department, Institute for Neurological 
      Research Raul Carrea (FLENI), Buenos Aires, Argentina.
FAU - Wainberg, F
AU  - Wainberg F
AD  - Movement Disorders Service, Neuroscience Department, Institute for Neurological 
      Research Raul Carrea (FLENI), Buenos Aires, Argentina.
FAU - Merello, M
AU  - Merello M
AD  - Movement Disorders Service, Neuroscience Department, Institute for Neurological 
      Research Raul Carrea (FLENI), Buenos Aires, Argentina; National Research Council 
      (CONICET), Buenos Aires, Argentina. Electronic address: mmerello@fleni.org.ar.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/complications
MH  - *Parkinsonian Disorders
MH  - Surveys and Questionnaires
EDAT- 2023/01/14 06:00
MHDA- 2023/02/08 06:00
CRDT- 2023/01/13 18:02
PHST- 2022/11/08 00:00 [received]
PHST- 2022/12/29 00:00 [revised]
PHST- 2023/01/08 00:00 [accepted]
PHST- 2023/01/14 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2023/01/13 18:02 [entrez]
AID - S1353-8020(23)00006-8 [pii]
AID - 10.1016/j.parkreldis.2023.105283 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2023 Feb;107:105283. doi: 
      10.1016/j.parkreldis.2023.105283. Epub 2023 Jan 9.