PMID- 36638601
OWN - NLM
STAT- MEDLINE
DCOM- 20230227
LR  - 20230227
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Linking)
VI  - 63
DP  - 2023 Apr
TI  - Clinical pathology of primary central nervous system lymphoma in HIV-positive 
      patients-a 41 Chinese patients retrospective study.
PG  - 152108
LID - S1092-9134(23)00005-9 [pii]
LID - 10.1016/j.anndiagpath.2023.152108 [doi]
AB  - OBJECTIVES: The purpose of this study was to investigate the clinicopathological 
      characteristics of primary central nervous system lymphoma (PCNSL). METHODS: We 
      collected 41 PCNSL formalin-fixed, paraffin-embedded (FFPE) samples from human 
      immunodeficiency virus (HIV)-positive patients and performed HE 
      (haematoxylin-eosin) staining, immunohistochemistry (IHC) staining, in situ 
      hybridization, fluorescence in situ hybridization (FISH). Real-time quantitative 
      polymerase chain reaction (RT-qPCR) was performed in 9 cases of FFPE samples. 
      Meanwhile, we analysed the clinical pathological significance of the results. 
      RESULTS: Seven patients had diffuse large B-cell lymphoma (DLBCL) with germinal 
      centre B-cell (GCB)-like DLBCL, 32 had activated B-cell (ABC)-like DLBCL, and 2 
      had Burkitt lymphoma (BL). GCB-like DLBCL patients were older at onset 
      (P = 0.040).A lower CD4(+) T-cell count and a decrease in cerebrospinal fluid 
      (CSF) glucose content were more frequent in ABC-like DLBCL (P = 0.012, 
      P = 0.006). Overexpression of P53 was more in ABC-like DLBCL (P = 0.041). 73.2 % 
      cases were Epstein-Barr encoding region (EBER) positive, which was more likely in 
      ABC-like DLBCL patients (P = 0.037). EBV DNA were detected in 5/7 EBER-negative 
      DLBCL cases and none (0/2) of the BL cases. All the cases were negative for HHV8 
      staining. None of the 7 Double expressor lymphoma (DEL) cases had BCL2, BCL6, or 
      c-MYC genetic rearrangements. CONCLUSIONS: HIV-related PCNSL showed unique 
      clinical pathological significance. None of EBV detected in HIV-related BL and 
      without HHV8 infectious are new sights in our single-center study of Chinese 
      HIV-related PCNSL patients.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Chen, Jiamin
AU  - Chen J
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Sun, Lei
AU  - Sun L
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Dai, Yuyang
AU  - Dai Y
AD  - National Institute for Drug Clinical Trial, Beijing Tongren Hospital, Capital 
      Medical University, Beijing 100730, China.
FAU - Zhang, Liang
AU  - Zhang L
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Yang, Kun
AU  - Yang K
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Han, Xiaoyi
AU  - Han X
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Ding, Xinghuan
AU  - Ding X
AD  - Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Gao, Haili
AU  - Gao H
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Zhou, Xingang
AU  - Zhou X
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Pathology, Beijing Ditan Hospital, Capital Medical University, 
      Beijing 100015, China. Electronic address: chinaroc001@126.com.
LA  - eng
PT  - Journal Article
DEP - 20230107
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
SB  - IM
MH  - Humans
MH  - Central Nervous System/pathology
MH  - East Asian People
MH  - *HIV Infections/complications
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma, Large B-Cell, Diffuse/pathology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Clinical pathology
OT  - HIV
OT  - Primary central nervous system lymphoma (PCNSL)
COIS- Declaration of competing interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2023/01/14 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/01/13 18:07
PHST- 2022/09/01 00:00 [received]
PHST- 2022/12/13 00:00 [revised]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2023/01/14 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/13 18:07 [entrez]
AID - S1092-9134(23)00005-9 [pii]
AID - 10.1016/j.anndiagpath.2023.152108 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2023 Apr;63:152108. doi: 10.1016/j.anndiagpath.2023.152108. 
      Epub 2023 Jan 7.