PMID- 36638958
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230402
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Linking)
VI  - 27
IP  - 1
DP  - 2023 Feb
TI  - The visual morbidity of optic nerve head drusen: a longitudinal review.
PG  - 30.e1-30.e5
LID - S1091-8531(23)00005-8 [pii]
LID - 10.1016/j.jaapos.2022.11.016 [doi]
AB  - BACKGROUND: The ophthalmologic complications of optic nerve head drusen (ONHD) in 
      adults have been documented, whereas data on the degree of visual morbidity from 
      OHND in children are limited. METHODS: The medical records of all patients 
      diagnosed with ONHD at a single, tertiary care ophthalmology department from 
      January 1, 2010, until July 1, 2018, were reviewed retrospectively. Patients were 
      identified using ICD-9 and ICD-10 codes. Inclusion criteria were age </=18 years of 
      age and formal documentation of ONHD by ancillary testing. RESULTS: A total of 
      213 patients (386 eyes with ONHD) met inclusion criteria. Mean age at diagnosis 
      was 10.13 +/- 4.09 years, and mean follow-up was 2.76 +/- 2.91 years. Formal visual 
      fields were available for 208 eyes. Repeatable visual field defects were noted in 
      24 eyes (11.5%). The most common defect was a nasal step, which occurred in 11 
      eyes (45.8%). Fifteen eyes had visual field defects at presentation, and 9 eyes 
      developed field loss within 1.39 +/- 0.55 years of diagnosis. There was no 
      correlation found between intraocular pressure and degree of visual field loss. 
      Choroidal neovascular membranes were clinically apparent in 5 eyes and treatment 
      was required in 3 eyes. Nonarteritic ischemic optic neuropathy developed in 2 
      eyes. CONCLUSIONS: Visual morbidity associated with ONHD in children is common 
      and may develop in a short period of time after initial diagnosis. There was no 
      correlation found with intraocular pressure.
CI  - Copyright (c) 2023 American Association for Pediatric Ophthalmology and Strabismus. 
      Published by Elsevier Inc. All rights reserved.
FAU - Gise, Ryan
AU  - Gise R
AD  - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, 
      and Harvard Medical School, Boston, Massachusetts.
FAU - Heidary, Gena
AU  - Heidary G
AD  - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, 
      and Harvard Medical School, Boston, Massachusetts. Electronic address: 
      Gena.Heidary@Childrens.Harvard.edu.
LA  - eng
PT  - Journal Article
DEP - 20230110
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
SB  - IM
MH  - Adult
MH  - Child
MH  - Humans
MH  - Adolescent
MH  - *Optic Disk
MH  - Retrospective Studies
MH  - *Optic Disk Drusen/complications
MH  - Visual Field Tests/adverse effects
MH  - Vision Disorders/diagnosis
MH  - Morbidity
MH  - Tomography, Optical Coherence
EDAT- 2023/01/14 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/01/13 19:25
PHST- 2022/07/04 00:00 [received]
PHST- 2022/11/13 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2023/01/14 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/13 19:25 [entrez]
AID - S1091-8531(23)00005-8 [pii]
AID - 10.1016/j.jaapos.2022.11.016 [doi]
PST - ppublish
SO  - J AAPOS. 2023 Feb;27(1):30.e1-30.e5. doi: 10.1016/j.jaapos.2022.11.016. Epub 2023 
      Jan 10.