PMID- 36639252 OWN - NLM STAT- MEDLINE DCOM- 20230323 LR - 20230417 IS - 2212-4411 (Electronic) VI - 135 IP - 3 DP - 2023 Mar TI - Oral manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis: an update and narrative review of the literature. PG - 372-384 LID - S2212-4403(22)01284-6 [pii] LID - 10.1016/j.oooo.2022.11.013 [doi] AB - Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystem disorder of small blood vessels subdivided into granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Oral manifestations (OMs) have been reported to include mucosal ulceration, gingival enlargement, alveolar bone necrosis, tooth loss, oro-antral communication, palatal perforation, parotitis, and candidal infection mainly in GPA. They may appear during the course of the disease, as a disease flare-up, or as the presenting sign. These OMs are often nonspecific and can mimic an array of conditions, therefore formulating a differential diagnosis can be challenging. This review updates the OMs of GPA, and, for the first, time includes OMs of other AAVs. It provides recommendations for the overall assessment and the diagnosis and management of all AAV OMs with considerations for treatment coordination. The role of oral health care providers in multidisciplinary care is highlighted. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Alamoudi, Waleed A AU - Alamoudi WA AD - Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; UCL Eastman Dental Institute, University College London, London, UK. FAU - Sollecito, Thomas P AU - Sollecito TP AD - University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. FAU - Stoopler, Eric T AU - Stoopler ET AD - University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. FAU - France, Katherine AU - France K AD - University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. Electronic address: kfrance@upenn.edu. LA - eng PT - Journal Article PT - Review DEP - 20221205 PL - United States TA - Oral Surg Oral Med Oral Pathol Oral Radiol JT - Oral surgery, oral medicine, oral pathology and oral radiology JID - 101576782 SB - IM MH - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications/diagnosis/therapy MH - Microscopic Polyangiitis/diagnosis MH - Churg-Strauss Syndrome/diagnosis MH - Granulomatosis with Polyangiitis/complications/diagnosis/therapy MH - *Oral Manifestations COIS- Declaration of interest None. EDAT- 2023/01/14 06:00 MHDA- 2023/03/22 06:00 CRDT- 2023/01/13 22:00 PHST- 2022/05/27 00:00 [received] PHST- 2022/11/17 00:00 [revised] PHST- 2022/11/20 00:00 [accepted] PHST- 2023/01/14 06:00 [pubmed] PHST- 2023/03/22 06:00 [medline] PHST- 2023/01/13 22:00 [entrez] AID - S2212-4403(22)01284-6 [pii] AID - 10.1016/j.oooo.2022.11.013 [doi] PST - ppublish SO - Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Mar;135(3):372-384. doi: 10.1016/j.oooo.2022.11.013. Epub 2022 Dec 5.