PMID- 36640061
OWN - NLM
STAT- MEDLINE
DCOM- 20230118
LR  - 20230118
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 21
IP  - 6
DP  - 2022 Dec 24
TI  - Effect of Temperature and Humidity on the Allegro-inflammatory Factors and 
      Allergic Rhinitis-related Behavior.
PG  - 704-710
LID - 10.18502/ijaai.v21i6.11531 [doi]
AB  - Allergic rhinitis (AR) is an allergic disease induced by the T helper 2 (TH2) 
      lymphocyte immune response, where its mediators are the primary cause of clinical 
      symptoms. Environmental factors are the primary determinants of the allergic 
      response in genetically susceptible individuals. This study investigates the 
      effects of climate conditions (warm, cold, humid, and dry) on allergic rhinitis. 
      AR models were created in mice under 4 different conditions. We investigated 
      AR-related behavior (sneezing and nose rubbing), as well as total immunoglobulin 
      E (IgE), histamine, interleukin-4 (IL-4), leukotriene (LT) B4 and LTC4 levels, 
      and gene expression of CysLT1R, HRH1, and MUC5a. Nose rubbing, histamine levels, 
      and the expression of MUC5a and HRH1 were increased in AR models in cold 
      conditions, and sneezing was increased in AR models kept in dry conditions. LTB4 
      and LTC4 levels and the expression of CysLT1R in AR models kept in a wet 
      environment also significantly increased compared with the control group. The 
      levels of total IgE and IL-4 showed no significant changes. Air temperature and 
      humidity affect AR pathophysiology, and weather conditions can be essential in 
      controlling AR.
FAU - Yonghua, Shen
AU  - Yonghua S
AD  - Department of Otolaryngology, The Affiliated Hospital of Yangzhou University, 
      Yangzhou University, Jiangsu, China. Emehrabinasab@gmail.com.
FAU - Mehrabi Nasab, Entezar
AU  - Mehrabi Nasab E
AD  - Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran 
      University of Medical Sciences, Tehran, Iran. Emehrabinasab@gmail.com.
FAU - Liuo, Yen
AU  - Liuo Y
AD  - Otorhinolaryngology Head and Neck Surgery, HongiHui Hospital, Xi'an University, 
      Xi'an, China. Almaatay@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221224
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 820484N8I3 (Histamine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 207137-56-2 (Interleukin-4)
RN  - 2CU6TT9V48 (Leukotriene C4)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Disease Models, Animal
MH  - Histamine
MH  - Humidity
MH  - Immunoglobulin E
MH  - *Interleukin-4
MH  - Leukotriene C4/adverse effects
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa
MH  - Ovalbumin
MH  - *Rhinitis, Allergic
MH  - Sneezing
MH  - Temperature
OTO - NOTNLM
OT  - Gene expression
OT  - Histamine
OT  - Leukotrienes
OT  - Sneezing
EDAT- 2023/01/15 06:00
MHDA- 2023/01/18 06:00
CRDT- 2023/01/14 08:41
PHST- 2022/05/14 00:00 [received]
PHST- 2022/10/08 00:00 [accepted]
PHST- 2023/01/14 08:41 [entrez]
PHST- 2023/01/15 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
AID - 10.18502/ijaai.v21i6.11531 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):704-710. doi: 
      10.18502/ijaai.v21i6.11531.