PMID- 36640062
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230117
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 21
IP  - 6
DP  - 2022 Dec 24
TI  - Identification of New Potential Allergens from Green-lipped Mussel (Perna 
      Canaliculus).
PG  - 711-715
LID - 10.18502/ijaai.v21i6.11532 [doi]
AB  - The green-lipped mussel (Perna canaliculus) originates from New Zealand. To 
      preserve the health benefits of green-lipped mussel meat, it is freeze-dried to 
      make a long-lasting powder. The powder is used to treat arthritis because of its 
      potential anti-inflammatory properties. The report describes a 54-year-old woman 
      who developed immediate rhinoconjunctival and respiratory symptoms after inhaling 
      green-lipped mussel powder she gave to her dog for arthritis. A skin prick test 
      with green-lipped mussel powder was performed. Protein extracts from P 
      canaliculus were separated by sodium dodecyl-sulfate polyacrylamide (SDS) gel 
      electrophoresis and probed with serum from patients and serum preincubated with 
      green-lipped mussel extract. Bound immunoglobulin E (IgE) was detected by 
      specific anti-human-IgE antibodies, and IgE-binding proteins were subsequently 
      identified by liquid chromatography and mass spectrometry. The skin prick test 
      was positive for green-lipped mussel. Specific IgE against green-lipped mussel 
      extract was detected using Western immunoblotting. These potential allergenic 
      proteins were identified by mass spectrometry as actin, tropomyosin, and 
      paramyosin. All three allergens are reported for the first time for P 
      canaliculus. Actin is a major allergen in Paphia textile, paramyosin in Sarcoptes 
      scarbiei, and tropomyosin in Haliotis discus. For all IgE-binding proteins, the 
      software AllCatPro predicted high allergenicity, supporting our conclusion that 
      these proteins from P canaliculus may also be allergenic. The identification of 
      allergens from P canaliculus provides the opportunity for specific tests to 
      assess the frequency of allergic reactions to P canaliculus.
FAU - Kage, Paula
AU  - Kage P
AD  - Department of Dermatology, Venereology and Allergology, UMC Leipzig, Leipzig, 
      Germany. paula.kage@uniklinik-leipzig.de.
FAU - Schubert, Kristin
AU  - Schubert K
AD  - Department of Molecular Systems Biology, Helmholtz-Centre for Environmental 
      Research, Leipzig, Germany. kristin.schubert@ufz.de.
FAU - Treudler, Regina
AU  - Treudler R
AD  - Department of Dermatology, Venereology and Allergology, UMC Leipzig, Leipzig, 
      Germany. regina.treudler@med.uni-leipzig.de.
FAU - Simon, Jan-Christoph
AU  - Simon JC
AD  - Department of Dermatology, Venereology and Allergology, UMC Leipzig, Leipzig, 
      Germany. jan-christoph.simon@med.uni-leipzig.de.
FAU - Von Bergen, Martin
AU  - Von Bergen M
AD  - Department of Molecular Systems Biology, Helmholtz-Centre for Environmental 
      Research, Leipzig, Germany AND Institute of Biochemistry, Faculty of Life 
      Sciences, University of Leipzig, Leipzig, Germany. martin.vonbergen@ufz.de.
FAU - Tomm, Janina
AU  - Tomm J
AD  - Department of Dermatology, Venereology and Allergology, UMC Leipzig, Leipzig, 
      Germany. tomm.janina@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20221224
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Tropomyosin)
RN  - 0 (Actins)
RN  - 0 (Allergens)
RN  - 0 (Powders)
SB  - IM
MH  - Female
MH  - Humans
MH  - Animals
MH  - Dogs
MH  - Tropomyosin
MH  - *Perna/chemistry
MH  - Actins
MH  - Allergens/chemistry
MH  - Powders
MH  - *Arthritis
OTO - NOTNLM
OT  - Anaphylaxis
OT  - Electrophoresis
OT  - IgE
OT  - Immunoblotting
OT  - Mussel
EDAT- 2023/01/15 06:00
MHDA- 2023/01/18 06:00
CRDT- 2023/01/14 08:41
PHST- 2021/10/12 00:00 [received]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2023/01/14 08:41 [entrez]
PHST- 2023/01/15 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
AID - 10.18502/ijaai.v21i6.11532 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):711-715. doi: 
      10.18502/ijaai.v21i6.11532.