PMID- 36641512 OWN - NLM STAT- MEDLINE DCOM- 20230412 LR - 20240507 IS - 1534-4681 (Electronic) IS - 1068-9265 (Print) IS - 1068-9265 (Linking) VI - 30 IP - 5 DP - 2023 May TI - The Impact of Lymphedema on Patient-Reported Outcomes After Breast Reconstruction: A Preliminary Propensity Score-Matched Analysis. PG - 3061-3071 LID - 10.1245/s10434-022-12994-z [doi] AB - BACKGROUND: Studies on the impact of secondary lymphedema on patient-reported satisfaction and quality of life following postmastectomy breast reconstruction are limited by their heterogeneity. We aimed to reduce heterogeneity in study sample populations and compare BREAST-Q Reconstruction Module scores of patients with lymphedema matched to patients without lymphedema. METHODS: We identified patients who underwent postmastectomy breast reconstruction from 2009 to 2017 and performed a propensity score-matched analysis to compare patient-reported outcomes of patients who developed lymphedema with those who did not. Matched covariates included age, body mass index, race/ethnicity, smoking history, radiation or chemotherapy exposure, postoperative infection, and reconstruction modality and laterality. Outcomes of interest were pre- and postoperative BREAST-Q scores for Satisfaction with Breasts, Physical Well-being of the Chest, Sexual Well-Being, and Psychosocial Well-Being; the minimal clinically important difference (MCID) was four points. RESULTS: Matched cohorts included 322 patients per group. Preoperative BREAST-Q scores did not differ between lymphedema and non-lymphedema matched cohorts. Postoperative BREAST-Q scores were significantly lower in lymphedema patients: Physical Well-Being of the Chest (all time points), Satisfaction with Breast (at 1 and 2 years), Sexual Well-Being (at 2 years), and Psychosocial Well-Being (at 2 and 3 years). All significant differences in average scores were greater than the MCID. CONCLUSIONS: Patients with breast cancer-related lymphedema reported significantly lower Physical Well-Being of the Chest, Satisfaction with Breasts, Sexual Well-Being, and Psychosocial Well-Being at various time points. Our findings may prove useful for patient counseling and justify the need for further research on the prevention and treatment of this devastating disease. CI - (c) 2023. Society of Surgical Oncology. FAU - Coriddi, Michelle AU - Coriddi M AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. coriddim@mskcc.org. FAU - Kim, Leslie N AU - Kim LN AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Haglich, Kathryn AU - Haglich K AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - McGrath, Leslie AU - McGrath L AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Monge, Jasmine J L AU - Monge JJL AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Shamsunder, Meghana G AU - Shamsunder MG AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Mehrara, Babak J AU - Mehrara BJ AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Dayan, Joseph H AU - Dayan JH AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. FAU - Nelson, Jonas A AU - Nelson JA AD - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 321 East 61st St, 6th Floor, New York, NY, USA. nelsonj1@mskcc.org. LA - eng GR - P30 CA008748/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20230115 PL - United States TA - Ann Surg Oncol JT - Annals of surgical oncology JID - 9420840 SB - IM MH - Humans MH - Female MH - Mastectomy/adverse effects/psychology MH - Quality of Life MH - Propensity Score MH - *Breast Neoplasms/surgery MH - *Mammaplasty/adverse effects/psychology MH - *Lymphedema/etiology MH - Patient Satisfaction MH - Patient Reported Outcome Measures PMC - PMC11071662 MID - NIHMS1982287 EDAT- 2023/01/15 06:00 MHDA- 2023/04/12 06:42 PMCR- 2024/05/06 CRDT- 2023/01/14 23:18 PHST- 2022/05/16 00:00 [received] PHST- 2022/12/06 00:00 [accepted] PHST- 2023/04/12 06:42 [medline] PHST- 2023/01/15 06:00 [pubmed] PHST- 2023/01/14 23:18 [entrez] PHST- 2024/05/06 00:00 [pmc-release] AID - 10.1245/s10434-022-12994-z [pii] AID - 10.1245/s10434-022-12994-z [doi] PST - ppublish SO - Ann Surg Oncol. 2023 May;30(5):3061-3071. doi: 10.1245/s10434-022-12994-z. Epub 2023 Jan 15.