PMID- 36642150 OWN - NLM STAT- MEDLINE DCOM- 20230130 LR - 20230202 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 316 DP - 2023 Mar TI - The combined effect of heavy metals and polycyclic aromatic hydrocarbons on arthritis, especially osteoarthritis, in the U.S. adult population. PG - 137870 LID - S0045-6535(23)00136-4 [pii] LID - 10.1016/j.chemosphere.2023.137870 [doi] AB - The evaluation of heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) impact on arthritis is usually limited to the analysis of the arthritis subtype (rheumatoid arthritis, RA), whereas studies on osteoarthritis (OA) are relatively sparse. Furthermore, the combined effect of HMs and PAHs co-exposure on arthritis also has rarely been analyzed. Herein, we aimed to comprehensively estimate the association between HMs and PAHs (three blood HMs and six urinary PAHs metabolites) co-exposure and arthritis. Using data from the National Health and Nutrition Examination Survey (NHANES), 2003-2016, we included 9735 adults, of whom 2464 had total arthritis, 1371 had OA, and 468 had RA. The logistic regression model was conducted to estimate the single effect of HMs and PAHs on arthritis. Moreover, weighted quantile sum (WQS) regression, quantile-based g computation (qgcomp), and Bayesian kernel machine regression (BKMR) were separately performed to assess the combined effect of HMs and PAHs co-exposure on arthritis. In the single-exposure analyses, cadmium (Cd) and lead (Pb) statistically grew the risk of total arthritis, OA, and RA. Among PAHs, 1-hydroxynaphthalene (1-NAP) and 3-hydroxyfluorene (3-FLU) showed a positive association with total arthritis, OA, and RA. Meanwhile, 2-NAP also was significantly associated with total arthritis. 2-NAP, 2-FLU, and 1-hydroxyphenanthrene (1-PHE) also were significantly associated with RA. Furthermore, the three complementary models consistently demonstrated that co-exposure to high levels of HMs and PAHs was positively associated with total arthritis, OA, and RA risk. The above associations were more obvious in young and medium-aged people. Interestingly, BKMR analyses indicated that 1-NAP might interact with Cd and 3-FLU in total arthritis, while Pb might interact with Cd in OA. Therefore, this study provided novel evidence that co-exposure to HMs and PAHs positively correlated with arthritis, especially OA, and these results were worthy of further prospective studies. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Fang, Lanlan AU - Fang L AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Zhao, Hui AU - Zhao H AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Chen, Yuting AU - Chen Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Ma, Yubo AU - Ma Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Xu, Shanshan AU - Xu S AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Xu, Shenqian AU - Xu S AD - Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230032, China. FAU - Pan, Guixia AU - Pan G AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Cai, Guoqi AU - Cai G AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. FAU - Shuai, Zongwen AU - Shuai Z AD - Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address: shuaizongwen@ahmu.edu.cn. FAU - Pan, Faming AU - Pan F AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic address: famingpan@ahmu.edu.cn. LA - eng PT - Journal Article DEP - 20230112 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - 141577-40-4 (N-(2-naphthalenesulfonyl)aspartyl-(2-phenethyl)amide) RN - 00BH33GNGH (Cadmium) RN - 2P299V784P (Lead) RN - 0 (Metals, Heavy) RN - 0 (Biomarkers) SB - IM MH - Adult MH - Humans MH - Aged MH - *Polycyclic Aromatic Hydrocarbons/analysis MH - Nutrition Surveys MH - Cadmium MH - Prospective Studies MH - Bayes Theorem MH - Lead MH - *Osteoarthritis/chemically induced/epidemiology MH - *Metals, Heavy MH - Biomarkers/urine OTO - NOTNLM OT - Arthritis OT - Combined effect OT - Heavy metals OT - NHANES OT - Osteoarthritis OT - Polycyclic aromatic hydrocarbons COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/01/16 06:00 MHDA- 2023/01/31 06:00 CRDT- 2023/01/15 19:23 PHST- 2022/09/09 00:00 [received] PHST- 2022/12/15 00:00 [revised] PHST- 2023/01/12 00:00 [accepted] PHST- 2023/01/16 06:00 [pubmed] PHST- 2023/01/31 06:00 [medline] PHST- 2023/01/15 19:23 [entrez] AID - S0045-6535(23)00136-4 [pii] AID - 10.1016/j.chemosphere.2023.137870 [doi] PST - ppublish SO - Chemosphere. 2023 Mar;316:137870. doi: 10.1016/j.chemosphere.2023.137870. Epub 2023 Jan 12.