PMID- 36643790
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230222
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2023
DP  - 2023
TI  - Brachial-Ankle Pulse Wave Velocity Mediates the Association between Increased Age 
      and Risk of Sarcopenia among Chinese Patients with Type 2 Diabetes Mellitus.
PG  - 3786342
LID - 10.1155/2023/3786342 [doi]
LID - 3786342
AB  - BACKGROUND AND AIMS: Arterial stiffness and sarcopenia are commonly seen in 
      patients with type 2 diabetes mellitus (T2DM), and both are age-related diseases. 
      However, few studies have addressed the causal relationship between age, arterial 
      stiffness, and sarcopenia, especially in patients with T2DM. This study is aimed 
      at investigating the relationship among age, arterial stiffness, and sarcopenia 
      in patients with T2DM. METHODS AND RESULTS: This cross-sectional study enrolled 
      557 inpatients with diabetes at the First Affiliated Hospital of Wenzhou Medical 
      University, China, between June 2020 and July 2021. Patients who were diagnosed 
      with T2DM and underwent examination of dual-energy X-ray absorptiometry, handgrip 
      strength, 6-meter walk speed, and brachial-ankle pulse wave velocity (baPWV, a 
      recognized indicator of arterial stiffness) were enrolled. A total of 447 
      patients were included. A dose-dependent relationship was found between age and 
      sarcopenia. We also found a dose-dependent relationship between age and baPWV. 
      Similarly, significant dose-dependent relationships were found across baPWV 
      tertiles with higher prevalence of sarcopenia. Then, a mediation analysis was 
      performed to explore the mediation effect of arterial stiffness on age-associated 
      sarcopenia. We found that the prevalence of sarcopenia increased by 0.0115 (95% 
      CI, 0.0028-0.0239) per 1 year increase in age by the mediation effect of baPWV 
      and that the direct effect of aging on sarcopenia was 0.0441 (95% CI, 
      0.0101-0.0909) per 1 year older. baPWV mediated 20.5% of the positive 
      relationship between increased age and the prevalence of sarcopenia. CONCLUSIONS: 
      Elevated baPWV partially mediates the association of age and sarcopenia among 
      patients with T2DM.
CI  - Copyright (c) 2023 Jiahong Jiang et al.
FAU - Jiang, Jiahong
AU  - Jiang J
AUID- ORCID: 0000-0003-0500-2278
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Zhang, Ping
AU  - Zhang P
AUID- ORCID: 0000-0002-0127-3591
AD  - The Second People's Hospital of Xining, Xining, Qinghai 816000, China.
FAU - Zhou, Zijun
AU  - Zhou Z
AUID- ORCID: 0000-0001-6197-7163
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Xu, Zeru
AU  - Xu Z
AUID- ORCID: 0000-0003-1508-190X
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Hu, Xiang
AU  - Hu X
AUID- ORCID: 0000-0002-6619-187X
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Yu, Weihui
AU  - Yu W
AUID- ORCID: 0000-0001-7384-0113
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Jiang, Feifei
AU  - Jiang F
AUID- ORCID: 0000-0002-2353-8554
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Pan, Yang
AU  - Pan Y
AUID- ORCID: 0000-0001-5928-6566
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Wang, Fei
AU  - Wang F
AUID- ORCID: 0000-0001-9675-8155
AD  - Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
FAU - Hong, Jing
AU  - Hong J
AUID- ORCID: 0000-0001-9265-5861
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Ye, Tingting
AU  - Ye T
AUID- ORCID: 0000-0002-5099-2066
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Xu, Ke
AU  - Xu K
AUID- ORCID: 0000-0001-6571-6796
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
FAU - Zhu, Hong
AU  - Zhu H
AUID- ORCID: 0000-0002-9024-0221
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, China.
AD  - Wenzhou Key Laboratory of Diabetes Research, Wenzhou, Zhejiang 325000, China.
LA  - eng
PT  - Journal Article
DEP - 20230106
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Ankle Brachial Index
MH  - *Sarcopenia/epidemiology
MH  - Risk Factors
MH  - Cross-Sectional Studies
MH  - Hand Strength
MH  - East Asian People
MH  - Pulse Wave Analysis
MH  - China/epidemiology
MH  - *Vascular Stiffness
PMC - PMC9839409
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2023/01/17 06:00
MHDA- 2023/01/18 06:00
PMCR- 2023/01/06
CRDT- 2023/01/16 02:47
PHST- 2022/10/19 00:00 [received]
PHST- 2022/12/18 00:00 [revised]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/01/16 02:47 [entrez]
PHST- 2023/01/17 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2023/01/06 00:00 [pmc-release]
AID - 10.1155/2023/3786342 [doi]
PST - epublish
SO  - J Diabetes Res. 2023 Jan 6;2023:3786342. doi: 10.1155/2023/3786342. eCollection 
      2023.