PMID- 36643844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230117
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Kimura's disease: A clinicopathological study of 23 cases.
PG  - 1069102
LID - 10.3389/fmed.2022.1069102 [doi]
LID - 1069102
AB  - INTRODUCTION: Kimura's disease (KD) is an uncommon lymphoproliferative 
      fibroinflammatory disorder. Patients present with head and neck subcutaneous 
      nodules with or without lymphadenopathy. Peripheral blood eosinophilia and 
      elevated serum immunoglobulin E (IgE) levels are typical. This study was designed 
      to delineate the clinicopathological features, pattern of care, and disease 
      course of 23 Taiwanese patients with KD. METHODS: We retrospectively analyzed the 
      clinical data of 23 consecutive cases (16 male and 7 female; age at diagnosis: 
      12-77 years) of KD diagnosed at our institution from 2015 to 2020. RESULTS: The 
      median time from presentation to diagnosis was 1 month. Twenty-one patients 
      presented with unilateral or bilateral head and neck masses. The remaining two 
      presented with right flank and right arm lesions, respectively. Peripheral blood 
      eosinophilia was observed in nine, and elevated IgE levels were observed in four. 
      All were diagnosed using either excisional or core-needle biopsy. Seven patients 
      underwent fine needle aspiration without a diagnostic yield. Salivary gland and 
      lymph node involvement was observed in three and seven patients, respectively. 
      Most lesions showed tissue eosinophilia (100%) and florid follicular hyperplasia 
      (78.26%). Three cases had histological KD-IgG4-RD overlap and three had comorbid 
      IgG4-RD were recognized. Thirteen patients underwent surgical resection, one 
      received adjuvant therapy, and two received prednisolone monotherapy. CONCLUSION: 
      KD should be considered in patients with subcutaneous masses, eosinophilia, and 
      elevated IgE levels. Biopsy remains the gold standard of diagnosis. Increased 
      recruitment of IgG4(+) plasma cells is a common feature. Consideration of IgG4-RD 
      in all KD patients may be prudent.
CI  - Copyright (c) 2022 Lee, Yu and Chan.
FAU - Lee, Chih-Chun
AU  - Lee CC
AD  - Department of Medical Education, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Yu, Kuang-Hui
AU  - Yu KH
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal 
      Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
FAU - Chan, Tien-Ming
AU  - Chan TM
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal 
      Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20221229
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9835107
OTO - NOTNLM
OT  - IgG4-related disease
OT  - Kimura's disease
OT  - Taiwan
OT  - eosinophilia
OT  - pathology
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/17 06:00
MHDA- 2023/01/17 06:01
PMCR- 2022/12/29
CRDT- 2023/01/16 02:48
PHST- 2022/10/31 00:00 [received]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2023/01/16 02:48 [entrez]
PHST- 2023/01/17 06:00 [pubmed]
PHST- 2023/01/17 06:01 [medline]
PHST- 2022/12/29 00:00 [pmc-release]
AID - 10.3389/fmed.2022.1069102 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Dec 29;9:1069102. doi: 10.3389/fmed.2022.1069102. 
      eCollection 2022.