PMID- 36644260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230117
IS  - 1881-641X (Print)
IS  - 1881-6428 (Electronic)
IS  - 1881-641X (Linking)
VI  - 15
IP  - 4
DP  - 2022 Dec 25
TI  - Anticoagulation Therapy for Pregnancy-Associated Thrombosis: A Retrospective 
      Observational Study.
PG  - 317-323
LID - 10.3400/avd.oa.22-00083 [doi]
AB  - Objectives: Pregnancy-associated deep vein thrombosis (DVT) is a rare disease, 
      and data on anticoagulation therapy are lacking. The present study examined the 
      treatment outcome with unfractionated heparin (UFH) subcutaneous injection in 
      patients with pregnancy-associated DVT. Methods: This single-center, 
      retrospective, observational study enrolled 15 patients with pregnancy-associated 
      DVT treated from January 2014 to April 2021. Results: The median age was 35 
      years. The median gestation week at onset was 10 (interquartile range is 8-11). 
      All patients presented with painful symptoms with edema. All patients had 
      proximal DVT. Anticoagulation therapy using UFH was performed in 14 patients. The 
      median continuous dose of heparin was 18,750 U/day, and the median subcutaneous 
      dose was 20,000 U/day. During the outpatient period, the values of activated 
      partial thromboplastin time fluctuated wildly, but the fibrin monomer complex 
      level remained consistently low. There were two mild bleeding complications, but 
      neither prevented the continuation of anticoagulation therapy. During delivery, 
      thrombi were not detected in 10 of 13 patients (77%), whereas three patients 
      (23%) exhibited regression without resolution of the thrombus. Conclusion: 
      Anticoagulation using UFH subcutaneous injection was safely performed in patients 
      with pregnancy-associated DVT without serious complications or progression of 
      thrombosis.
CI  - (c) 2022 The Editorial Committee of Annals of Vascular Diseases.
FAU - Umetsu, Michihisa
AU  - Umetsu M
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Akamatsu, Daijirou
AU  - Akamatsu D
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Serizawa, Fukashi
AU  - Serizawa F
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Tajima, Yuta
AU  - Tajima Y
AD  - Sendai City Hospital, Sendai, Miyagi, Japan.
FAU - Suzuki, Shunya
AU  - Suzuki S
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Horii, Shinichiro
AU  - Horii S
AD  - Iwate Prefectural Isawa Hospital, Ohshu, Iwate, Japan.
FAU - Ogasawara, Norinobu
AU  - Ogasawara N
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Takahashi, Hirokazu
AU  - Takahashi H
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Nagaoka, Yohei
AU  - Nagaoka Y
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Shimizu, Kota
AU  - Shimizu K
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Kimura, Shunsaku
AU  - Kimura S
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
FAU - Hashimoto, Munetaka
AU  - Hashimoto M
AD  - Iwate Prefectural Isawa Hospital, Ohshu, Iwate, Japan.
FAU - Goto, Hitoshi
AU  - Goto H
AD  - South Miyagi Medical Center, Shibata, Miyagi, Japan.
FAU - Watanabe, Tetsuo
AU  - Watanabe T
AD  - Sendai City Hospital, Sendai, Miyagi, Japan.
FAU - Kamei, Takashi
AU  - Kamei T
AD  - Tohoku University Hospital, Sendai, Miyagi, Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Ann Vasc Dis
JT  - Annals of vascular diseases
JID - 101471467
PMC - PMC9816033
OTO - NOTNLM
OT  - DVT
OT  - VTE
OT  - anticoagulation
OT  - heparin
OT  - pregnancy
COIS- Disclosure StatementThe authors declare no conflict of interest for this article.
EDAT- 2023/01/17 06:00
MHDA- 2023/01/17 06:01
PMCR- 2022/12/25
CRDT- 2023/01/16 02:58
PHST- 2022/07/31 00:00 [received]
PHST- 2022/10/23 00:00 [accepted]
PHST- 2023/01/16 02:58 [entrez]
PHST- 2023/01/17 06:00 [pubmed]
PHST- 2023/01/17 06:01 [medline]
PHST- 2022/12/25 00:00 [pmc-release]
AID - 10.3400/avd.oa.22-00083 [doi]
PST - ppublish
SO  - Ann Vasc Dis. 2022 Dec 25;15(4):317-323. doi: 10.3400/avd.oa.22-00083.