PMID- 36645710 OWN - NLM STAT- MEDLINE DCOM- 20230310 LR - 20240402 IS - 1097-0142 (Electronic) IS - 0008-543X (Print) IS - 0008-543X (Linking) VI - 129 IP - 7 DP - 2023 Apr 1 TI - Emotional, behavioral, and physical health consequences of loneliness in young adult survivors of childhood cancer: Results from the Childhood Cancer Survivor Study. PG - 1117-1128 LID - 10.1002/cncr.34633 [doi] AB - BACKGROUND: Young adults in the general population are at risk of experiencing loneliness, which has been associated with physical and mental health morbidities. The prevalence and consequences of loneliness in young adult survivors of childhood cancer remain unknown. METHODS: A total of 9664 young adult survivors of childhood cancer (median age at diagnosis 10.5 years [interquartile range (IQR), 5-15], 27.1 years at baseline [IQR, 23-32]) and 2221 siblings enrolled in the Childhood Cancer Survivor Study completed a self-reported survey question assessing loneliness on the Brief Symptom Inventory-18 at baseline and follow-up (median follow-up, 6.6 years). Multivariable models evaluated the prevalence of loneliness at baseline only, follow-up only, and baseline + follow-up, and its associations with emotional distress, health behaviors, and chronic conditions at follow-up. RESULTS: Survivors were more likely than siblings to report loneliness at baseline + follow-up (prevalence ratio [PR] 2.2; 95% confidence interval [CI], 1.7-3.0) and at follow-up only (PR, 1.4; 95% CI, 1.1-1.7). Loneliness at baseline + follow-up was associated with elevated risk of anxiety (relative risk [RR], 9.8; 95% CI, 7.5-12.7), depression (RR, 17.9; 95% CI, 14.1-22.7), and current smoking (odds ratio [OR], 1.7; 95% CI, 1.3-2.3) at follow-up. Loneliness at follow-up only was associated with suicidal ideation (RR, 1.5; 95% CI, 1.1-2.1), heavy/risky alcohol consumption (RR, 1.3; 95% CI, 1.1-1.5), and new-onset grade 2-4 chronic conditions (RR, 1.3; 95% CI, 1.0-1.7). CONCLUSIONS: Young adult survivors of childhood cancer have elevated risk of experiencing loneliness, which is associated with future emotional distress, risky health behaviors, and new-onset chronic conditions. CI - (c) 2023 American Cancer Society. FAU - Papini, Chiara AU - Papini C AUID- ORCID: 0000-0002-5338-4154 AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Fayad, Ameera A AU - Fayad AA AD - School of Nursing, Washington State University, Seattle, Washington, USA. FAU - Wang, Mingjuan AU - Wang M AD - Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Schulte, Fiona S M AU - Schulte FSM AUID- ORCID: 0000-0002-3076-9676 AD - Department of Psychology, University of Calgary, Calgary, Alberta, Canada. FAU - Huang, I-Chan AU - Huang IC AUID- ORCID: 0000-0002-1194-3923 AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Chang, Yu-Ping AU - Chang YP AD - University at Buffalo School of Nursing, The State University of New York, New York, New York, USA. FAU - Howell, Rebecca M AU - Howell RM AD - Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. FAU - Srivastava, Deokumar AU - Srivastava D AD - Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Leisenring, Wendy M AU - Leisenring WM AUID- ORCID: 0000-0001-7405-0906 AD - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. FAU - Armstrong, Gregory T AU - Armstrong GT AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Gibson, Todd M AU - Gibson TM AD - National Cancer Institute, Bethesda, Maryland, USA. FAU - Robison, Leslie L AU - Robison LL AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Oeffinger, Kevin C AU - Oeffinger KC AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA. FAU - Krull, Kevin R AU - Krull KR AUID- ORCID: 0000-0002-0476-7001 AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Brinkman, Tara M AU - Brinkman TM AUID- ORCID: 0000-0002-4250-6160 AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. LA - eng GR - P30 CA014236/CA/NCI NIH HHS/United States GR - P30 CA021765/CA/NCI NIH HHS/United States GR - U24 CA055727/CA/NCI NIH HHS/United States GR - UL1 TR001412/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230116 PL - United States TA - Cancer JT - Cancer JID - 0374236 SB - IM MH - Humans MH - Child MH - Young Adult MH - *Cancer Survivors MH - *Neoplasms/epidemiology/therapy/complications MH - Loneliness MH - Survivors MH - Chronic Disease MH - Risk Factors PMC - PMC9998368 MID - NIHMS1864292 OTO - NOTNLM OT - childhood cancer OT - loneliness OT - quality of life OT - survivorship OT - young adult COIS- Conflict of interest disclosures The authors have no relevant disclosures. EDAT- 2023/01/17 06:00 MHDA- 2023/03/11 06:00 PMCR- 2024/04/01 CRDT- 2023/01/16 11:53 PHST- 2022/10/27 00:00 [revised] PHST- 2022/08/09 00:00 [received] PHST- 2022/12/01 00:00 [accepted] PHST- 2023/01/17 06:00 [pubmed] PHST- 2023/03/11 06:00 [medline] PHST- 2023/01/16 11:53 [entrez] PHST- 2024/04/01 00:00 [pmc-release] AID - 10.1002/cncr.34633 [doi] PST - ppublish SO - Cancer. 2023 Apr 1;129(7):1117-1128. doi: 10.1002/cncr.34633. Epub 2023 Jan 16.