PMID- 36647882
OWN - NLM
STAT- MEDLINE
DCOM- 20230118
LR  - 20230501
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 27
IP  - 1
DP  - 2023 Jan
TI  - Intermittent fasting in type 2 diabetes: from fundamental science to clinical 
      applications.
PG  - 333-351
LID - 30880 [pii]
LID - 10.26355/eurrev_202301_30880 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a huge challenge for global public health 
      systems. Currently, healthcare policies advocate the prevention of the onset and 
      progression of T2DM by improving individual lifestyles. The increasing benefits 
      of intermittent fasting (IF) as a dietary intervention have been elucidated. 
      However, the beneficial effects of IF in T2DM remain inconclusive. We 
      demonstrated the physiological mechanisms underlying the positive effects of IF 
      in T2DM. IF could trigger metabolic transformation to improve systemic metabolism 
      and induce tissue-specific metabolic adaptations through alterations in the gut 
      microbiota, adipose tissue remodeling, correction of circadian rhythm 
      disturbances, and increased autophagy in peripheral tissues. The efficacy and 
      safety of IF regimens in clinical applications carry a risk of hypoglycemia and 
      require monitoring of blood glucose and timely adjustment of medications. 
      However, there is limited evidence of a positive effect of IF in weight loss and 
      improvement of glycemic variables. Overall, IF serves as a promising therapeutic 
      target for T2DM and needs to be established by a large randomized controlled 
      trial.
FAU - Chen, L
AU  - Chen L
AD  - First School of Clinical Medicine, Fourth School of Clinical Medicine, Zhejiang 
      Chinese Medical University, Hangzhou, Zhejiang, China. 19843012@zcmu.edu.cn.
FAU - Tian, F-Y
AU  - Tian FY
FAU - Hu, X-H
AU  - Hu XH
FAU - Wu, J-W
AU  - Wu JW
FAU - Xu, W-D
AU  - Xu WD
FAU - Huang, Q
AU  - Huang Q
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Intermittent Fasting
MH  - Blood Glucose/metabolism
MH  - *Hypoglycemia
MH  - Obesity
MH  - Fasting
EDAT- 2023/01/18 06:00
MHDA- 2023/01/19 06:00
CRDT- 2023/01/17 06:03
PHST- 2023/01/17 06:03 [entrez]
PHST- 2023/01/18 06:00 [pubmed]
PHST- 2023/01/19 06:00 [medline]
AID - 30880 [pii]
AID - 10.26355/eurrev_202301_30880 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2023 Jan;27(1):333-351. doi: 
      10.26355/eurrev_202301_30880.